The pre-conception maternal exposure to Sofosbuvir affects the mitochondrial biogenesis in prenatal fetal tissues: Experimental study on rats

SA Mahmoud, MM Abdel-Aziz, RHM Khafaga… - Molecular …, 2023 - Springer
Abstract Background Hepatitis C virus (HCV) infection is a global public health problem and
Egypt has the highest HCV prevalence worldwide. Hence, global efforts target to eliminate …

The Intergeneration Long-Lasting Consequences of Pre-Conceptional Exposure to Sofosbuvir on the Ovarian Tissues of F1 Offspring: Experimental Study on Rats

HA Hafez, SA Mahmoud, JF Alhmoud… - International Journal of …, 2023 - mdpi.com
Sofosbuvir (SOF), a nucleos (t) ide polymerase inhibitor, has been used during the past
decade for mass treatment of viral hepatitis C in endemic countries like Egypt, increasing the …

The deleterious effects of sofosbuvir and ribavirin (antiviral drugs against hepatitis C virus) on different body systems in male albino rats regarding reproductive …

RA Ali, EA Awadalla, YA Amin, SS Fouad… - Scientific Reports, 2024 - nature.com
Sofosbuvir is one of the crucial drugs used in the treatment of chronic hepatitis C virus (HCV)
in adults and children with compensated liver disease, including cirrhosis. It may be used …

Effect of sofosbuvir (sovaldi) on the fundic mucosa of adult male albino rats and the possible protective role of fucoidan: Histological, histochemical, and …

DE Elghazouly, RI Yassien - Egyptian Journal of Histology, 2022 - ejh.journals.ekb.eg
Background: Sofosbuvir (SOF) is a hopeful remedy for chronic hepatitis C virus infection.
However, it records some unfavorable influences on gastrointestinal tract. Fucoidan is a …

Direct-Acting Antiviral Drug Modulates the Mitochondrial Biogenesis in Different Tissues of Young Female Rats

HA Hafez, AM Atoom, RHM Khafaga… - International Journal of …, 2023 - mdpi.com
(1) Background: Hepatitis C virus (HCV) infection is endemic in Egypt, with the highest
prevalence rate worldwide. Sofosbuvir (SOF) is a nucleos (t) ide analog that specifically …

Saffron extract attenuates Sofosbuvir‐induced retinal neurodegeneration in albino rat

WS Elseady, WA Keshk, WA Negm… - The Anatomical …, 2023 - Wiley Online Library
Sofosbuvir is a novel drug candidate for the treatment of hepatitis C viral infection; however,
vision loss is one of its growing adverse effects. Saffron is a natural biomolecule with a high …

[PDF][PDF] Maha Abd‑El Baki Ahmed 5, Mohammed H. Hassan 6, Emaad Abdel‑Kahaar 7, 8 & Rehab H. Abdel‑Aziz 9

RA Ali, EA Awadalla, YA Amin, SS Fouad - Scientific Reports, 2024 - researchgate.net
Scientific Reports|(2024) 14: 5682| https://doi. org/10.1038/s41598-024-55950-5 www.
nature. com/scientificreports/triglyceride, and lipase, which exhibit a significant increase …

[HTML][HTML] Effect of sofosbuvir administration and its withdrawal on the submandibular salivary gland of adult male albino rats: A histological and ultra-structural study

AM Abdeen, T Essawy… - Open Access Macedonian …, 2019 - ncbi.nlm.nih.gov
BACKGROUND: Sofosbuvir (SOF) was approved in 2013 as a part of first-line treatment for
hepatitis C virus (HCV); it has activity against all genotypes with extrahepatic adverse effects …

Histological and biochemical studies on effect of Sofosbuvir (Sovaldi) on adult male albino rat kidney

AF Mohamed, AM Abo-Ouf, MAA Arafa - Ultrastructural Pathology, 2021 - Taylor & Francis
Sofosbuvir (sovaldi) is the backbone of many anti‐HCV drugs. We aimed to demonstrate the
effect of sofosbuvir on the adult male albino rat kidney. Sixty adult male albino rats were …

Histological and Immunohistochemical Study of the Effect of Sofosbuvir and its withdrawal on the Submandibular salivary glands and Tongue of Adult Male Albino …

SM Badr, EM El-Beltagi… - … and Biomedical Journal, 2025 - bbj.journals.ekb.eg
Hepatitis C virus (HCV) infection has been considered a core reason of chronic liver
disorder. Sofosbuvir (SOF) is part of a combined antiviral therapy regimen used to treat …