Nephrotoxicity is one of the most important side effects and therapeutical limitations of
aminoglycoside antibiotics, especially gentamicin. Despite rigorous patient monitoring …

Aminoglycoside antibiotics are employed clinically because of their potent bactericidal
activities, less bacterial resistance, post-antibiotic effects and low cost. However, drugs …

Introduction: Gentamicin sulphate nephrotoxicity seems to be attributed to the generation of
reactive oxygen species. Olive leaf extract (OLE) has been demonstrated to have antioxidant …

The present investigation reports the effect of rosmarinic acid (RA), an antioxidant on
gentamicin sulphate (GS)-induced renal oxidative damage in rats. Rosmarinic acid (RA) has …

Natural and chemical toxic agents cause severe adverse effects on people's health in a
variety of exposing ways. Herbal medications have taken into consideration as alternative …

Kidney injury is a relatively common complication of the use of aminoglycosides.
Inflammation and oxidative stress play a key role in gentamicin (GM) nephrotoxicity. We …

Background. Our previous study showed that kallikrein gene transfer protects against
gentamicin-induced nephrotoxicity and enhances renal function. In this study, we …

Gentamicin is a commonly used aminoglycoside antibiotic. However, its therapeutic use is
limited by its nephrotoxicity. The mechanisms of gentamicin-induced nephrotoxicity are …

The potential protective role of aminoguanidine (AG), gadolinium chloride (GdCl3) and
oleanolic acid (OA) in acetaminophen (APAP)-induced hepatotoxicity and nephrotoxicity …

The present study was aimed to investigate the possible protective effects of thymoquinone
(TQ) and curcumin (Cur) on gentamicin (GM)-induced nephrotoxicity in rats. Rats were …