Hydrolytic Stability of Unsubstituted Hydrazones of Aromatic Carbonyl Compounds in Reversed-Phase HPLC
A Deruish, GV Karakashev, AI Ukolov… - Journal of Analytical …, 2023 - Springer
Abstract Unsubstituted hydrazones RR′ C= NNH2 are unstable during gas
chromatographic separation. Testing of their resistance to hydrolysis under reversed-phase …
chromatographic separation. Testing of their resistance to hydrolysis under reversed-phase …
Development of Hyphenated Techniques and Network Identification Approaches for Biotransformational Evaluation of Promising Antitubercular N-pyrrolyl hydrazide …
Novel, rapid and precise RP-HPLC–DAD method was developed, validated and
successfully applied for determination of metabolic changes of ethyl 5-(4-bromophenyl)-1-(3 …
successfully applied for determination of metabolic changes of ethyl 5-(4-bromophenyl)-1-(3 …
Synthesis, Biological Evaluation, Molecular Docking and ADME Studies of Novel Pyrrole-Based Schiff Bases as Dual Acting MAO/AChE Inhibitors
Considering the complex pathogenesis of Alzheimer's disease (AD), the multitarget ligand
strategy is expected to provide superior effects for the treatment of the neurological disease …
strategy is expected to provide superior effects for the treatment of the neurological disease …
[PDF][PDF] Biological evaluation, molecular docking and DFT calculations of pyrrole-based derivatives as dual acting AChE/MAO-B inhibitors.
E Mateev, M Georgieva - Pharmacia (0428-0296), 2023 - pharmacia.pensoft.net
Considering the complex pathophysiology of Alzheimer's disease (AD), the multitarget
ligand strategy is expected to provide superior effects for the treatment of the neurological …
ligand strategy is expected to provide superior effects for the treatment of the neurological …
Об устойчивости незамещенных гидразонов ароматических карбонильных соединений к гидролизу в условиях обращенно-фазовой ВЭЖХ
А Деруиш, ГВ Каракашев, АИ Уколов… - Žurnal analitičeskoj …, 2023 - journals.rcsi.science
Соединения ряда незамещенных гидразонов RR′ C= NNH 2 отличаются
нестабильностью в ходе газохроматографического разделения. Проверка их …
нестабильностью в ходе газохроматографического разделения. Проверка их …
[PDF][PDF] Optimization and validation of RP-HPLC method for evaluation of pyrrole-containing hydrazones in isolated rat synaptosomes
A Mateeva, M Kondeva-Burdina, L Peikova… - …, 2023 - pharmacia.pensoft.net
In the current study, RP-HPLC method for evaluation of 2 pyrrol-based hydrazones in
isolated rat synaptosomes was optimized and validated according to ICH guidelines. The …
isolated rat synaptosomes was optimized and validated according to ICH guidelines. The …
Metabolic stability of a hydrazone derivative: N′-[(4-chlorophenyl) methylidene)]-4-[(4-methylphenyl) sulfonyloxy] benzohydrazide
Metabolic stability, a key parameter in drug development, refers to a drug substance's
resistance to metabolism. The failure rate can be significantly reduced by conducting …
resistance to metabolism. The failure rate can be significantly reduced by conducting …