Insights into the antimicrobial properties of hepcidins: advantages and drawbacks as potential therapeutic agents

L Lombardi, G Maisetta, G Batoni, A Tavanti - Molecules, 2015 - mdpi.com
The increasing frequency of multi-drug resistant microorganisms has driven research into
alternative therapeutic strategies. In this respect, natural antimicrobial peptides (AMPs) hold …

Adding functions to biomaterial surfaces through protein incorporation

MA Wronska, IB O'Connor, MA Tilbury… - Advanced …, 2016 - Wiley Online Library
The concept of biomaterials has evolved from one of inert mechanical supports with a long‐
term, biologically inactive role in the body into complex matrices that exhibit selective cell …

Improved Expression of a Thermostable GH18 Bacterial Chitinase in Two Different Escherichia coli Strains and Its Potential Use in Plant Protection and Biocontrol of …

A Ezzine, S Ben Hadj Mohamed, S Bezzine… - Molecular …, 2024 - Springer
Chitinases are enzymes that can break down chitin, a major component of the exoskeleton
of insects and fungi. This feature makes them potential biopesticides in agriculture since …

Regional and Seasonal Variability of Mineral Patterns in Some Organs of Slaughtered One-Humped Camels [Camelus dromedarius] from Saudi Arabia

MM Abdelrahman, IA Alhidary, MM Alobre, AM Matar… - Animals, 2022 - mdpi.com
Simple Summary Camel products are receiving great interest worldwide because of their
high functional properties and nutritive values, but concern regarding their high content of …

Hepcidin in non-alcoholic fatty liver disease regulated by the TLR4/NF-κB signaling pathway

WEI Chen, X Wang, LI Huang… - Experimental and …, 2016 - spandidos-publications.com
The aim of our study was to analyze the role of toll-like receptor 4 (TLR4)/nuclear factor (NF)-
κB signal pathway on Hepcidin regulation in non‑alcoholic fatty liver disease (NAFLD). A …

Hepcidin cDNA evolution in vertebrates

M Boumaiza, S Abidi - Vitamins and Hormones, 2019 - Elsevier
Hepcidin, belonging to the β-defensin family, was isolated for the first time from plasma and
human urine. It is a cationic peptide, rich in cysteine bound with four disulfide bridges, which …

Expression and purification of a new recombinant camel hepcidin able to promote the degradation of the iron exporter ferroportin1

M Boumaiza, M Jaouen, JC Deschemin… - Protein Expression and …, 2015 - Elsevier
Abstract Hepcidin, a 25-amino-acid and highly disulfide bonded antimicrobial peptide, is the
central regulator of iron homeostasis. This hormone is expressed in response to iron and …

大西洋庸鲽(Hippoglossus hippoglossus L.) hipposin 抗菌肽在毕赤酵母中的表达及其纯化

李文婧, 陶妍 - 生物学杂志, 2016 - swxzz.com
Hipposin 是大西洋庸鲽(Hippoglossus hippoglossus L.) 组蛋白H2A 的N 端衍生物, 共含51
个氨基酸残基, 具有抑制革兰氏阳性和阴性菌的活性. 根据毕赤酵母密码子偏爱性对编码 …

Recombinant overexpression of camel hepcidin cDNA in Pichia pastoris: purification and characterization of the polyHis‐tagged peptide HepcD‐His

M Boumaiza, H Chahed, A Ezzine… - Journal of Molecular …, 2017 - Wiley Online Library
Hepcidin, a liver‐expressed antimicrobial peptide, has been demonstrated to act as an iron
regulatory hormone as well as to exert a wide spectrum of antimicrobial activity. The aim of …

Production and characterization of functional recombinant hybrid heteropolymers of camel hepcidin and human ferritin H and L chains

M Boumaiza, F Carmona, M Poli… - Protein Engineering …, 2017 - academic.oup.com
Hepcidin is a liver-synthesized hormone that plays a central role in the regulation of
systemic iron homeostasis. To produce a new tool for its functional properties the cDNA …