Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling
organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most …

The ConSurf web‐sever for the analysis of proteins, RNA, and DNA provides a quick and
accurate estimate of the per‐site evolutionary rate among homologues. The analysis reveals …

Membrane-sculpting proteins shape the morphology of cell membranes and facilitate
remodeling in response to physiological and environmental cues. Complexes of the …

Caveolins are a family of membrane-bound scaffolding proteins that compartmentalize and
negatively regulate signal transduction. Recent studies have implicated a loss of caveolin-1 …

Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling
regulators with numerous partners and whose activity is highly dependent on cellular …

Cancer stem cells (CSCs) possess the capacity to self-renew and to generate
heterogeneous lineages of cancer cells that comprise tumors. A substantial body of …

Resistance of solid tumors to chemo‐and radiotherapy remains a major obstacle in anti‐
cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is …

Individualizing cancer therapy for molecular targeted inhibitors requires a new class of
molecular profiling technology that can map the functional state of the cancer cell signal …

Here, we set out to test the novel hypothesis that increased mitochondrial biogenesis in
epithelial cancer cells would “fuel” enhanced tumor growth. For this purpose, we generated …