Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Liver metastasis is highly aggressive and treatment-refractory, partly due to macrophage-
mediated immune suppression. Understanding the mechanisms leading to functional …

Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …

Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …

Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

CD36, a scavenger receptor expressed in multiple cell types, mediates lipid uptake,
immunological recognition, inflammation, molecular adhesion, and apoptosis. CD36 is a …

Metabolic reprogramming is a new hallmark of cancer but it remains poorly defined in
hepatocellular carcinogenesis (HCC). The fatty acid receptor CD36 is associated with both …