How to sensitize glioblastomas to temozolomide chemotherapy: A gap-centered view
Temozolomide (TMZ) is a methylating agent used as the first-line drug in the chemotherapy
of glioblastomas. However, cancer cells eventually acquire resistance, necessitating the …
of glioblastomas. However, cancer cells eventually acquire resistance, necessitating the …
Havoc in harmony: Unravelling the intricacies of angiogenesis orchestrated by the tumor microenvironment
SS Acharya, CN Kundu - Cancer Treatment Reviews, 2024 - Elsevier
Cancer cells merely exist in isolation; rather, they exist in an intricate microenvironment
composed of blood vessels, signalling molecules, immune cells, stroma, fibroblasts, and the …
composed of blood vessels, signalling molecules, immune cells, stroma, fibroblasts, and the …
Near infrared-responsive quinacrine–gold hybrid nanoparticles deregulate HSP-70/P300-mediated H3K14 acetylation in ER/PR+ breast cancer stem cells
Aim: This study aimed to determine if quinacrine–gold hybrid nanoparticles (QAuNPs)+ near-
infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen …
infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen …
Targeted Treatment against Cancer Stem Cells in Colorectal Cancer
J Martínez-Pérez, C Torrado… - International Journal of …, 2024 - mdpi.com
The cancer stem cell (SC) theory proposes that a population of SCs serves as the driving
force behind fundamental tumor processes, including metastasis, recurrence, and resistance …
force behind fundamental tumor processes, including metastasis, recurrence, and resistance …
Scaffold overlay of flavonoid-inspired molecules: Discovery of 2, 3-diaryl-pyridopyrimidin-4-imine/ones as dual hTopo-II and tubulin targeting anticancer agents
Almost half of all medicines approved by the US Food and Drug Administration have been
found to be developed based on inspiration from natural products (NPs). Here, we report a …
found to be developed based on inspiration from natural products (NPs). Here, we report a …
Veliparib exerts protective effects in intracerebral hemorrhage mice by inhibiting the inflammatory response and accelerating hematoma resolution
Y Fu, R Liu, Y Zhao, Y Xie, H Ren, Y Wu, B Zhang… - Brain Research, 2024 - Elsevier
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors have potent anti-inflammatory
effects, including the suppression of brain microglial activation. Veliparib, a well-known …
effects, including the suppression of brain microglial activation. Veliparib, a well-known …
Resveratrol nanoparticles induce apoptosis in oral cancer stem cells by disrupting the interaction between β-catenin and GLI-1 through p53-independent activation of …
Cancer stem cells (CSCs) are mainly responsible for tumorigenesis, chemoresistance, and
cancer recurrence. CSCs growth and progression are regulated by multiple signaling …
cancer recurrence. CSCs growth and progression are regulated by multiple signaling …
Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents
DNA polymerase β (Polβ) is crucial for the base excision repair (BER) pathway of DNA
damage repair and is an attractive target for suppressing tumorigenesis as well as …
damage repair and is an attractive target for suppressing tumorigenesis as well as …
Nimbolide: A Potential Phytochemical Agent in Multimodal Pancreatic Cancer Therapies
M Jogi, H Asnani, S Singh… - Mini-Reviews in Medicinal …, 2025 - benthamdirect.com
A significant contributor to cancer-related death, pancreatic cancer (PC) has a terrible
prognosis in general that has not altered over many years. Currently, it is extremely difficult …
prognosis in general that has not altered over many years. Currently, it is extremely difficult …