The β Subunit of Voltage-Gated Ca2+ Channels
Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …
contraction, neuronal communication, hormone release, cell division, and gene …
Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation–contraction coupling to mutations that cause inherited arrhythmia
JA Keefe, OM Moore, KS Ho, XHT Wehrens - Archives of toxicology, 2023 - Springer
Abstract Calcium (Ca2+) ions are a key second messenger involved in the rhythmic
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …
Genome-wide association study of blood pressure and hypertension
Blood pressure is a major cardiovascular disease risk factor. To date, few variants
associated with interindividual blood pressure variation have been identified and replicated …
associated with interindividual blood pressure variation have been identified and replicated …
Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death
E Burashnikov, R Pfeiffer, H Barajas-Martinez… - Heart rhythm, 2010 - Elsevier
BACKGROUND: L-type calcium channel (LTCC) mutations have been associated with
Brugada syndrome (BrS), short QT (SQT) syndrome, and Timothy syndrome (LQT8). Little is …
Brugada syndrome (BrS), short QT (SQT) syndrome, and Timothy syndrome (LQT8). Little is …
Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia
Q Zhang, J Chen, Y Qin, J Wang, L Zhou - Channels, 2018 - Taylor & Francis
The voltage-gated L-type calcium channel (LTCC) is essential for multiple cellular
processes. In the heart, calcium influx through LTCC plays an important role in cardiac …
processes. In the heart, calcium influx through LTCC plays an important role in cardiac …
Akt regulates L-type Ca2+ channel activity by modulating Cavα1 protein stability
D Catalucci, DH Zhang, J DeSantiago, F Aimond… - Journal of Cell …, 2009 - rupress.org
The insulin IGF-1–PI3K–Akt signaling pathway has been suggested to improve cardiac
inotropism and increase Ca2+ handling through the effects of the protein kinase Akt …
inotropism and increase Ca2+ handling through the effects of the protein kinase Akt …
Genetic variations in CYP17A1, CACNB2 and PLEKHA7 are associated with blood pressure and/or hypertension in She ethnic minority of China
Y Lin, X Lai, B Chen, Y Xu, B Huang, Z Chen, S Zhu… - Atherosclerosis, 2011 - Elsevier
OBJECTIVES: Two large-scale genome-wide association studies (GWAs) have identified
multiple variants associated with blood pressure (BP) or hypertension. The present study …
multiple variants associated with blood pressure (BP) or hypertension. The present study …
CaMKII associates with CaV1.2 L‐type calcium channels via selected β subunits to enhance regulatory phosphorylation
SA Abiria, RJ Colbran - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 112, 150–161. Abstract Calcium/calmodulin‐dependent kinase II
(CaMKII) facilitates L‐type calcium channel (LTCC) activity physiologically, but may …
(CaMKII) facilitates L‐type calcium channel (LTCC) activity physiologically, but may …
Molecular determinants of the Cavβ-induced plasma membrane targeting of the Cav1. 2 channel
B Bourdin, F Marger, S Wall-Lacelle… - Journal of Biological …, 2010 - ASBMB
Ca V β subunits modulate cell surface expression and voltage-dependent gating of high
voltage-activated (HVA) Ca V 1 and Ca V 2 α1 subunits. High affinity Ca V β binding onto the …
voltage-activated (HVA) Ca V 1 and Ca V 2 α1 subunits. High affinity Ca V β binding onto the …
Role of CACNA1C in Brugada syndrome: Prevalence and phenotype of probands referred for genetic testing
Background Evidence for the role of the CACNA1C gene, which encodes for the α-subunit of
the cardiac L-type calcium channel CaV1. 2, as a cause of the BrS3 variant of Brugada …
the cardiac L-type calcium channel CaV1. 2, as a cause of the BrS3 variant of Brugada …