New finds in the palaeoanthropological and genomic records have changed our view of the
origins of modern human ancestry. Here we review our current understanding of how the …

Nearly all genetic variants that influence disease risk have human-specific origins; however,
the systems they influence have ancient roots that often trace back to evolutionary events …

Alleles that introgress between species can influence the evolutionary and ecological fate of
species exposed to novel environments. Hybrid offspring of different species are often unfit …

The past few years have witnessed a revolution in our ability to obtain DNA from ancient
humans. This important new data has added to our knowledge from archaeology and …

Hybridization is an evolutionary phenomenon that has fascinated biologists for centuries.
Prior to the advent of whole-genome sequencing, it was clear that hybridization had played …

Genome-scale sequence data have invigorated the study of hybridization and introgression,
particularly in animals. However, outside of a few notable cases, we lack systematic tests for …

To date, the only Neandertal genome that has been sequenced to high quality is from an
individual found in Southern Siberia. We sequenced the genome of a female Neandertal …

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk
globally. Large-scale schizophrenia genetic studies have reported primarily on European …

In the past decade, advances in genome sequencing have allowed researchers to uncover
the history of hybridization in diverse groups of species, including our own. Although the …

INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present …