Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2023 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
Tryptophan metabolites as mediators of microbiota-gut-brain communication: focus on isatin
A Medvedev, O Buneeva - Frontiers in Behavioral Neuroscience, 2022 - frontiersin.org
Isatin (indole-2, 3-dione) is an endogenous regulator, exhibiting various behavioral,
biological, and pharmacological activities. Synthesis of isatin includes several crucial …
biological, and pharmacological activities. Synthesis of isatin includes several crucial …
Molecular spectroscopy evidence of 1, 3, 5-tris (4-carboxyphenyl) benzene binding to DNA: anticancer potential along with the comparative binding profile of …
One of medicinal chemistry's top priorities is the discovery of new molecules with anticancer
potential. Compounds that interact with DNA are an intriguing family of chemotherapeutic …
potential. Compounds that interact with DNA are an intriguing family of chemotherapeutic …
Augmented anticancer effect and antibacterial activity of silver nanoparticles synthesized by using Taxus wallichiana leaf extract
Background Taxus wallichiana is an evergreen tree species found in the Himalayan region
of Pakistan. The tree possesses important secondary metabolites such as Taxol that has …
of Pakistan. The tree possesses important secondary metabolites such as Taxol that has …
Minor groove binding of antihistamine drug bilastine with calf thymus DNA: A molecular perspective with thermodynamics using experimental and theoretical methods
Molecular recognition which are driven by molecular interactions, is of great interest in drug
discovery and targeted drug delivery systems since drugs exhibit their medicinal …
discovery and targeted drug delivery systems since drugs exhibit their medicinal …
Synthesis, X-ray, DFT, Hirshfeld surface analysis, molecular docking, urease inhibition, antioxidant, cytotoxicity, DNA protection, and DNA binding properties of 5-(tert-butyl)-N-(2 …
(Tert-butyl)-N-(2, 4-dichlorophenyl)-1 H-1, 2, 4-triazol-3-amine was synthesized in four steps
starting from pivalic acid via thiourea formation followed by heterocyclization with hydrazine …
starting from pivalic acid via thiourea formation followed by heterocyclization with hydrazine …
Spectro-electrochemical, fluorometric and biothermodynamic evaluation of pharmacologically active morpholine scaffold single crystal ligand and its metal (II) …
A novel series of metal (II) complexes (1–5)[M II (L) 2]{Where M= Cu (1), Co (2), Mn (3), Ni
(4) and Zn (5)} constructed from 2-(4-morpholinobenzylideneamino) phenol Schiff base …
(4) and Zn (5)} constructed from 2-(4-morpholinobenzylideneamino) phenol Schiff base …
Investigation of Newly Synthesized Bis-Acyl-Thiourea Derivatives of 4-Nitrobenzene-1, 2-Diamine for Their DNA Binding, Urease Inhibition, and Anti-Brain-Tumor …
Bis-acyl-thiourea derivatives, namely N, N'-(((4-nitro-1, 2-phenylene) bis (azanediyl)) bis
(carbonothioyl)) bis (2, 4-dichlorobenzamide)(UP-1), N, N'-(((4-nitro-1, 2-phenylene) bis …
(carbonothioyl)) bis (2, 4-dichlorobenzamide)(UP-1), N, N'-(((4-nitro-1, 2-phenylene) bis …
Exploration of newly synthesized amantadine-thiourea conjugates for their DNA binding, anti-elastase, and anti-glioma potentials
Three newly synthesized amantadine thiourea conjugates namely MS-1 N-(((3 s, 5 s, 7 s)-
adamantan-1-yl) carbamothioyl) benzamide, MS-2 N-(((3 s, 5 s, 7 s)-adamantan-1-yl) …
adamantan-1-yl) carbamothioyl) benzamide, MS-2 N-(((3 s, 5 s, 7 s)-adamantan-1-yl) …
Exploring the antioxidant, antimicrobial, cytotoxic and biothermodynamic properties of novel morpholine derivative bioactive Mn (ii), Co (ii) and Ni (ii) complexes …
A novel class of bioactive complexes (1–3)[MII (L) 2 (bpy)], where, L= 2-(4-
morpholinobenzylideneamino) phenol, bpy= 2, 2′-bipyridine, MII= Mn (1), Co (2) or Ni (3) …
morpholinobenzylideneamino) phenol, bpy= 2, 2′-bipyridine, MII= Mn (1), Co (2) or Ni (3) …