In vitro modeling of the neurovascular unit: advances in the field

A Bhalerao, F Sivandzade, SR Archie… - Fluids and Barriers of …, 2020 - Springer
The blood–brain barrier (BBB) is a fundamental component of the central nervous system. Its
functional and structural integrity is vital in maintaining the homeostasis of the brain …

Knowledge gaps in generating cell-based drug delivery systems and a possible meeting with artificial intelligence

N Mozafari, N Mozafari, A Dehshahri… - Molecular …, 2023 - ACS Publications
Cell-based drug delivery systems are new strategies in targeted delivery in which cells or
cell-membrane-derived systems are used as carriers and release their cargo in a controlled …

From cells to organoids: The evolution of blood-brain barrier technology for modelling drug delivery in brain cancer

E Gonzales-Aloy, A Ahmed-Cox, M Tsoli… - Advanced Drug Delivery …, 2023 - Elsevier
Brain cancer remains the deadliest cancer. The blood–brain barrier (BBB) is impenetrable to
most drugs and is a complex 3D network of multiple cell types including endothelial cells …

Recent progress in microfluidic models of the blood-brain barrier

L Jiang, S Li, J Zheng, Y Li, H Huang - Micromachines, 2019 - mdpi.com
The blood-brain barrier (BBB) is a critical physical and chemical barrier that maintains brain
homeostasis. Researchers in academia and industry are highly motivated to develop …

Advances in research of adult gliomas

A Finch, G Solomou, V Wykes, U Pohl… - International journal of …, 2021 - mdpi.com
Diffuse gliomas are the most frequent brain tumours, representing 75% of all primary
malignant brain tumours in adults. Because of their locally aggressive behaviour and the fact …

Blood brain barrier-on-a-chip to model neurological diseases

S Reshma, KB Megha, S Amir, S Rukhiya… - Journal of Drug Delivery …, 2023 - Elsevier
The blood-brain barrier (BBB) is a vital and unique multi-dimensional selective barrier that
helps maintain brain homeostasis. BBB is a complex and dynamic structure responsible for …

Blood brain barrier permeability prediction using machine learning techniques: an update

D Saxena, A Sharma, MH Siddiqui… - Current pharmaceutical …, 2019 - ingentaconnect.com
Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of
permeability that allow a limited range of drug and compounds to pass through it. The BBB …

Modeling of ultra-small lipid nanoparticle surface charge for targeting glioblastoma

M Mendes, A Miranda, T Cova, L Goncalves… - European Journal of …, 2018 - Elsevier
Surface modification of ultra-small nanostructured lipid carriers (usNLC) via introduction of a
positive charge is hypothesized to prompt site-specific drug delivery for glioblastoma …

Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A computationally guided experimental approach

M Mendes, J Basso, J Silva, T Cova, J Sousa… - International Journal of …, 2020 - Elsevier
Ultra-small nanostructured lipid carriers (usNLCs) are stable, biocompatible and
biodegradable colloidal systems, claiming a broad set of advanced features suitable for …

Advances in astrocyte computational models: from metabolic reconstructions to multi-omic approaches

J González, A Pinzón, A Angarita-Rodríguez… - Frontiers in …, 2020 - frontiersin.org
The growing importance of astrocytes in the field of neuroscience has led to a greater
number of computational models devoted to the study of astrocytic functions and their …