Osteosarcoma (OS) is the most common primary malignancy of the bone and has a high
propensity for local invasion and metastasis. Although combining surgery with …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Purpose The outcome for patients with metastatic or recurrent sarcoma remains poor.
Adoptive therapy with tumor-directed T cells is an attractive therapeutic option but has never …

Osteosarcoma (OS) is the most common primary malignancy of bone and patients with
metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little …

Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents,
and the 5-year event-free survival rate has not improved significantly in the past three …

NK cells have therapeutic potential for a wide variety of human malignancies. However,
because NK cells expand poorly in vitro, have limited life spans in viv o, and represent a …

Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing
calcified osteoid extracellular matrix and inducing lung metastases with a high frequency …

Adoptive immunotherapy with natural killer cells was pioneered 30 years ago in human
clinical trials with the development of cytokine‐induced killer cells—unfractionated …

The antitumor functions of NK cells are regulated by the integration of positive and negative
signals triggered by numerous membrane receptors present on the NK cells themselves …

In the last decade, an impressive advance was achieved in adoptive cell therapy (ACT),
which has improved therapeutic potential and significant value in promising cancer …