Highlights•Isoprenoid precursors and CoA are essential metabolites generated by
apicoplast-localized enzymes.•Isoprenoids play an essential role in apicoplast …

Malaria is a parasitic disease that remains a global health issue, responsible for a significant
death and morbidity toll. Various factors have impacted the use and delayed the …

The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by
actively scavenging multiple carbon sources and essential nutrients from its host cell …

Plasmodium falciparum infects millions and kills thousands of people annually the world
over. With the emergence of artemisinin and/or multidrug resistant strains of the pathogen, it …

Efforts to control the global malaria health crisis are undermined by antimalarial resistance.
Identifying mechanisms of resistance will uncover the underlying biology of the Plasmodium …

Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an
important role in regulating multiple pathways in Plasmodium falciparum central carbon …

Although apatinib is a promising drug for the treatment of liver cancer, the underlying drug
resistance mechanism is still unclear. Here, we constructed apatinib-resistant HepG2 cells …

New pyridine‐based chalcones 4a–h and pyrazolines 5a–h (N‐acetyl), 6a–h (N‐phenyl),
and 7a–h (N‐4‐chlorophenyl) were synthesized and evaluated by the National Cancer …

We recently reported that SF2312 ((1, 5-dihydroxy-2-oxopyrrolidin-3-yl) phosphonic acid), a
phosphonate antibiotic with a previously unknown mode of action, is a potent inhibitor of the …

Drug resistance is a major healthcare challenge, resulting in a continuous need to develop
new inhibitors. The development of these inhibitors requires an understanding of the …