Leprosy as a genetic disease

A Alter, A Grant, L Abel, A Alcaïs, E Schurr - Mammalian genome, 2011 - Springer
Leprosy (Hansen's disease) is a human infectious disease whose etiological agent,
Mycobacterium leprae, was identified by GHA Hansen in the 19th century. Despite the high …

El factor de necrosis tumoral α (TNF-α) en las enfermedades autoinmunes (EA): biología molecular y genética

JM Fragoso, GV Alarcón, SJ Morales… - Gaceta Médica de …, 2014 - medigraphic.com
It has been estimated that autoimmune diseases (AIDs) affect 5-8% of the US population.
AIDs are a serious public health problem worldwide. These diseases are chronic conditions …

Liraglutide attenuates restenosis after vascular injury in rabbits with diabetes via the TGF-β/Smad3 signaling pathway

HX Ding, NXD MM, CX Zhou, FJW MM… - … therapies in health …, 2022 - search.proquest.com
Background* Lower limb ischemia due to arterial stenosis is a major complication in patients
with diabetes mellitus (DM). Liraglutide is a long-acting analogue of a glucagonlike peptide …

Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis

IR Mangangcha, P Jha, K Arora, M Mukerji… - Infection, Genetics and …, 2011 - Elsevier
Abstract Globally only 5–10% of people encountering Mycobacterium tuberculosis have a
lifetime risk of active disease indicating a strong host genetic bias towards development of …

TNF-α and TNF-β gene polymorphism in Saudi rheumatoid arthritis patients

H Al-Rayes, R Al-Swailem, M Albelawi… - Clinical Medicine …, 2011 - journals.sagepub.com
Background Tumor necrosis factor (TNF)-α and-β are cytokines with a wide range of
inflammatory, apoptotic and immunomodulatory activities. TNF-α promoter–308 G< A …

Tumour necrosis factor gene polymorphisms in Egyptian patients with rheumatoid arthritis and their relation to disease activity and severity

H Zaghlol, S Abdelshafy, R Mohamed… - … European Journal of …, 2019 - termedia.pl
Results TNF-α 308 G allele and TNF-α 308 GG genotype were significantly higher in RA
patients compared to healthy control subjects (p= 0.04 and p= 0.001, respectively). TNF-α …

Inflammation-related cytokine gene polymorphisms in Behçet's disease

F Al-Okaily, M Arfin, S Al-Rashidi… - Journal of …, 2015 - Taylor & Francis
Behçet's disease (BD) is a complex, multisystemic inflammatory disorder of unclear etiology.
Single nucleotide polymorphisms in tumor necrosis factor (TNF) and interleukin (IL)-10 …

Genetic polymorphisms located in TGFB1, AGTR1, and VEGFA genes are associated to chronic renal allograft dysfunction

MA Jiménez-Sousa, A Fernández-Rodríguez… - Cytokine, 2012 - Elsevier
BACKGROUND: Persistent inflammation and fibrosis have been related to active
progression of renal deterioration and reduced survival of kidney transplant. The aim of this …

Association of single‐nucleotide polymorphisms in tumour necrosis factor and human leukocyte antigens genes with type 1 diabetes

AE Osman, I Brema, A AlQurashi… - International Journal …, 2021 - Wiley Online Library
Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by progressive
destruction of insulin‐producing pancreatic beta cells. This multifactorial disease has a …

[HTML][HTML] Association of inflammation gene polymorphism with increased risk of metabolic syndrome in tatar ethnic group

OV Kochetova, DS Avzaletdinova… - Russian Open Medical …, 2022 - cyberleninka.ru
Background and objective-Chronic low-grade inflammation plays an important role in
pathophysiology of metabolic syndrome (MetS). The aim of our study was to determine the …