Treatment resistance in psychiatry: state of the art and new directions
OD Howes, ME Thase, T Pillinger - Molecular psychiatry, 2022 - nature.com
Abstract Treatment resistance affects 20–60% of patients with psychiatric disorders; and is
associated with increased healthcare burden and costs up to ten-fold higher relative to …
associated with increased healthcare burden and costs up to ten-fold higher relative to …
Digital era 4.0: The contribution to education and student psychology
This study aims to explain the challenges of teachers in the digital era 4.0 and readiness to
face these challenges. Through literature review. The author explains that there are several …
face these challenges. Through literature review. The author explains that there are several …
A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials
L Sforzini, C Worrell, M Kose, IM Anderson… - Molecular …, 2022 - nature.com
Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …
Comparative efficacy of racemic ketamine and esketamine for depression: a systematic review and meta-analysis
A Bahji, GH Vazquez, CA Zarate Jr - Journal of affective disorders, 2021 - Elsevier
Background Ketamine appears to have a therapeutic role in certain mental disorders, most
notably depression. However, the comparative performance of different formulations of …
notably depression. However, the comparative performance of different formulations of …
Efficacy and safety of fixed-dose esketamine nasal spray combined with a new oral antidepressant in treatment-resistant depression: results of a randomized, double …
M Fedgchin, M Trivedi, EJ Daly… - International Journal …, 2019 - academic.oup.com
Background About one-third of patients with depression fail to achieve remission despite
treatment with multiple antidepressants and are considered to have treatment-resistant …
treatment with multiple antidepressants and are considered to have treatment-resistant …
Depression in the primary care setting
LT Park, CA Zarate Jr - New England Journal of Medicine, 2019 - Mass Medical Soc
Key Clinical Points Depression in the Primary Care Setting Screening for depression and
suicidal thinking and behavior is important in the primary care setting. Distinguishing …
suicidal thinking and behavior is important in the primary care setting. Distinguishing …
Ketamine for the acute treatment of severe suicidal ideation: double blind, randomised placebo controlled trial
Objective To confirm the rapid onset anti-suicidal benefits of ketamine in the short term and
at six weeks, overall and according to diagnostic group. Design Prospective, double blind …
at six weeks, overall and according to diagnostic group. Design Prospective, double blind …
A systematic review and meta-analysis of the efficacy of intravenous ketamine infusion for treatment resistant depression: January 2009–January 2019
WS Marcantoni, BS Akoumba, M Wassef… - Journal of affective …, 2020 - Elsevier
Background Sub-anaesthetic administration of ketamine is an emerging practice in patients
presenting treatment resistant depression (TRD), however several outstanding questions …
presenting treatment resistant depression (TRD), however several outstanding questions …
Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised …
MA Nettis, G Lombardo, C Hastings… - …, 2021 - nature.com
This study aimed to investigate the role of baseline levels of peripheral inflammation when
testing the efficacy of antidepressant augmentation with minocycline in patients with …
testing the efficacy of antidepressant augmentation with minocycline in patients with …