A simple method for developing lysine targeted covalent protein reagents
R Gabizon, B Tivon, RN Reddi… - Nature …, 2023 - nature.com
Peptide-based covalent probes can target shallow protein surfaces not typically addressable
using small molecules, yet there is a need for versatile approaches to convert native peptide …
using small molecules, yet there is a need for versatile approaches to convert native peptide …
Novel non-opioid analgesics in pain management
TG Pulskamp, LM Johnson, DJ Berlau - Pain Management, 2024 - Taylor & Francis
Effective pain management has long been hindered by the limitations and risks associated
with opioid analgesics, necessitating the exploration of novel, non-opioid alternatives. A …
with opioid analgesics, necessitating the exploration of novel, non-opioid alternatives. A …
Finding new analgesics: Computational pharmacology faces drug discovery challenges
Despite the worldwide prevalence and huge burden of pain, pain is an undertreated
phenomenon. Currently used analgesics have several limitations regarding their efficacy …
phenomenon. Currently used analgesics have several limitations regarding their efficacy …
Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli
Introduction Chronic itch is a central symptom of atopic dermatitis. Cutaneous afferent
neurons express receptors interleukins (IL)-4, IL-13, and IL-33, which are type 2 cytokines …
neurons express receptors interleukins (IL)-4, IL-13, and IL-33, which are type 2 cytokines …
Leveraging a meta-learning approach to advance the accuracy of Nav blocking peptides prediction
The voltage-gated sodium (Nav) channel is a crucial molecular component responsible for
initiating and propagating action potentials. While the α subunit, forming the channel pore …
initiating and propagating action potentials. While the α subunit, forming the channel pore …
Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations
We introduce a computational approach for the design of target-specific peptides. Our
method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta …
method integrates a Gated Recurrent Unit-based Variational Autoencoder with Rosetta …
Harnessing Deep Learning Methods for Voltage-Gated Ion Channel Drug Discovery
Voltage-gated ion channels (VGICs) are pivotal in regulating electrical activity in excitable
cells and are critical pharmaceutical targets for treating many diseases including cardiac …
cells and are critical pharmaceutical targets for treating many diseases including cardiac …
Emerging Medications and Strategies in Acute Pain Management: Evolving Role of Novel Sodium and Calcium Channel Blockers, Peptide-Based Pharmacologic …
AD Kaye, DR Greene, C Nguyen, A Ragland… - Current Pain and …, 2024 - Springer
Abstract Purpose of Review The present investigation evaluated integration of novel
medication technology to enhance treatment options, while improving patient outcomes in …
medication technology to enhance treatment options, while improving patient outcomes in …
Venom-derived peptides for breaking through the glass ceiling of drug development
Venoms are complex mixtures produced by animals and consist of hundreds of components
including small molecules, peptides, and enzymes selected for effectiveness and efficacy …
including small molecules, peptides, and enzymes selected for effectiveness and efficacy …
Harnessing deep learning methods for voltage-gated ion channel drug discovery
D Lopez-Mateos, BJ Harris… - …, 2025 - journals.physiology.org
Voltage-gated ion channels (VGICs) are pivotal in regulating electrical activity in excitable
cells and are critical pharmaceutical targets for treating many diseases including cardiac …
cells and are critical pharmaceutical targets for treating many diseases including cardiac …