The implication of oxidative stress and AMPK-Nrf2 antioxidative signaling in pneumonia pathogenesis

W Xu, T Zhao, H Xiao - Frontiers in Endocrinology, 2020 - frontiersin.org
It is widely recognized that chemical, physical, and biological factors can singly or
synergistically evoke the excessive production of oxidative stress in pulmonary tissue that …

IRW (Isoleucine–Arginine–Tryptophan) Improves Glucose Tolerance in High Fat Diet Fed C57BL/6 Mice via Activation of Insulin Signaling and AMPK Pathways in …

SC de Campos Zani, M Son, KS Bhullar, CB Chan… - Biomedicines, 2022 - mdpi.com
IRW (Isoleucine–Arginine–Tryptophan), has antihypertensive and anti-inflammatory
properties in cells and animal models and prevents angiotensin-II-and tumor necrosis factor …

SNAP23 is required for constitutive and regulated exocytosis in mouse oocytes

LM Mehlmann, TF Uliasz, KM Lowther - Biology of reproduction, 2019 - academic.oup.com
Mammalian oocytes are stored in the ovary for prolonged periods, and arrested in meiotic
prophase. During this period, their plasma membranes are constantly being recycled by …

Gain-of-Function Dynamin-2 Mutations Linked to Centronuclear Myopathy Impair Ca2+-Induced Exocytosis in Human Myoblasts

L Bayonés, MJ Guerra-Fernández… - International Journal of …, 2022 - mdpi.com
Gain-of-function mutations of dynamin-2, a mechano-GTPase that remodels membrane and
actin filaments, cause centronuclear myopathy (CNM), a congenital disease that mainly …

Regulated resurfacing of a somatostatin receptor storage compartment fine-tunes pituitary secretion

W Alshafie, V Francis, K Bednarz, YE Pan… - Journal of Cell …, 2020 - rupress.org
The surfacing of the glucose transporter GLUT4 driven by insulin receptor activation
provides the prototypic example of a homeostasis response dependent on mobilization of an …

Multiorgan metabolomics and Lipidomics provide new insights into fat infiltration in the liver, muscle wasting, and liver–muscle crosstalk following Burn injury

S Mert, B Bulutoglu, C Chu, M Dylewski… - Journal of Burn Care …, 2021 - academic.oup.com
Burn injury mediated hypermetabolic syndrome leads to increased mortality among severe
burn victims, due to liver failure and muscle wasting. Metabolic changes may persist up to 2 …

[HTML][HTML] Anti-diabetic activity of extract from Morus nigra L. twigs through activation of AMPK/PKC pathway in mice

P Tang, X Yang, H Chen, T Zhang, H Tang… - Journal of Functional …, 2022 - Elsevier
Morus nigra L. is a traditional ethnomedicinal plants, which is used for the treatment of
atherosclerosis, diabetes, hyperlipidemia, and hypertension. The aim of this study was to …

[HTML][HTML] (+)-Catechin & proanthocyanidin fraction of uncaria gambir roxb. Improve adipocytes differentiation & glucose uptake of 3t3-l1 cells via sirtuin-1, peroxisome …

S Arundita, F Ismed, RS Rita… - Advanced Pharmaceutical …, 2020 - ncbi.nlm.nih.gov
Purpose: To improve adipocytes differentiation & glucose uptake activity of 3T3-L1 cells
through sirtuin-1, peroxisome proliferator-activated receptor γ (PPAR γ), glucose transporter …

Phenotypic characterization of a novel type 2 diabetes animal model in a SHANXI MU colony of Chinese hamsters

L Wang, C Wang, R Zhang, Y Liu, C Wang, G Song… - Endocrine, 2019 - Springer
Purpose Developing animal models for human diseases is critical for studying complex
diseases such as type 2 diabetes mellitus (T2DM). Since inbred colonies of Chinese …

The effect of cassia seed extract on the regulation of the LKB1–AMPK–GLUT4 signaling pathway in the skeletal muscle of diabetic rats to improve the insulin sensitivity …

QY Wang, AH Tong, YY Pan, XD Zhang… - Diabetology & Metabolic …, 2019 - Springer
Background This study aimed to observe the hypoglycemic effect of cassia seed extract in
rats with type-2 diabetes mellitus and its effect on reducing insulin resistance in the skeletal …