Aging of the vasculature plays a central role in morbidity and mortality of older people. To
develop novel treatments for amelioration of unsuccessful vascular aging and prevention of …

In 2009, rapamycin was reported to increase the lifespan of mice when implemented later in
life. This observation resulted in a sea-change in how researchers viewed aging. This was …

Vascular dementia (VaD) is a second most common form of age-related dementia. It is
characterized by cognitive impairment associated with vascular pathology, symptoms mainly …

Atherosclerosis is one of the main underlying causes of cardiovascular diseases (CVD). It is
associated with chronic inflammation and intimal thickening as well as the involvement of …

An intact blood-brain barrier (BBB) limits entry of proinflammatory and neurotoxic blood-
derived factors into the brain parenchyma. The BBB is damaged in Alzheimer's disease …

Vascular dysfunction is a universal feature of aging and decreased cerebral blood flow has
been identified as an early event in the pathogenesis of Alzheimer9s disease (AD) …

There has been an increasing appreciation of the role of vascular contributions to cognitive
impairment and dementia (VCID) associated with old age. Strong preclinical and …

Cerebrovascular dysfunction and cognitive decline are highly prevalent in aging, but the
mechanisms underlying these impairments are unclear. Cerebral blood flow decreases with …

The gut microbiome interacts with the brain bidirectionally through the microbiome-gutbrain
axis, which plays a key role in regulating various nervous system pathophysiological …

Age‐related cognitive failure is a main devastating incident affecting even healthy people.
Alzheimer's disease (AD) is the utmost common form of dementia among the geriatric …