The development and progression of diabetic kidney disease (DKD), a highly prevalent
complication of diabetes mellitus, are influenced by both genetic and environmental factors …

Significance: Intrarenal oxidative stress plays a critical role in the initiation and progression
of diabetic kidney disease (DKD). Enhanced oxidative stress results from overproduction of …

Diabetic retinopathy (DR) is a leading cause of vision-loss globally. Of an estimated 285
million people with diabetes mellitus worldwide, approximately one third have signs of DR …

Diabetic nephropathy (DN) is a chronic, inflammatory disease affecting millions of diabetic
patients worldwide. DN is associated with proteinuria and progressive slowing of glomerular …

Diabetic nephropathy (DN), a severe microvascular complication frequently associated with
both type 1 and type 2 diabetes mellitus, is a leading cause of renal failure. The condition …

Diabetic nephropathy is a major cause of ESRD worldwide. Despite its prevalence, a lack of
reliable animal models that mimic human disease has delayed the identification of specific …

The endothelium is a complex organ with a multitude of properties essential for control of
vascular functions. Dysfunction of the vascular endothelium is regarded as an important …

Chronic renal and vascular oxidative stress in association with an enhanced inflammatory
burden are determinant processes in the development and progression of diabetic …

Nephropathy is a major complication of diabetes. Alterations of mesangial cells have
traditionally been the focus of research in deciphering molecular mechanisms of diabetic …

Diabetes is a worldwide epidemic that has led to a rise in diabetic kidney disease (DKD).
Over the past two decades, there has been significant clarification of the various pathways …