Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Nitric oxide (NO) induces a multitude of antitumor activities, encompassing the induction of
apoptosis, sensitization to chemo-, radio-, or immune-therapy, and inhibition of metastasis …

In photodynamic therapy (PDT), the concentration of reactive oxygen species (ROS)
generated in cells directly determines the therapeutic effect. However, excessive glutathione …

The heme in the active center of peroxidases reacts with hydrogen peroxide to form highly
reactive intermediates, which then oxidize simple substances called peroxidase substrates …

Cyclosporine A (CsA) is a widely used immunosuppressive agent that greatly reduces the
rates of kidney-, heart-, and liver-transplant rejection. However, CsA nephrotoxicity is a …

Background and Aims During liver fibrosis, liver sinusoidal endothelial cells (LSECs)
release angiocrine signals to recruit inflammatory cells into the liver. p300, a master …

Electronic cigarette (e-cig) vaping (ECV) has been proposed as a safer alternative to
tobacco cigarette smoking (TCS); however, this remains controversial due to a lack of long …

We recently reported a mouse model of chronic electronic cigarette (e-cig) exposure-
induced cardiovascular pathology, where long-term exposure to e-cig vape (ECV) induces …