In multiple sclerosis—the archetypal inflammatory response in the central nervous system—
T cells and macrophages invade the brain and damage the myelin and neurons. In other …

Transmissible spongiform encephalopathies form a group of fatal neurodegenerative
disorders that have the unique property of being infectious, sporadic or genetic in origin …

Prion diseases are fatal, chronic neurodegenerative diseases of mammals, characterized by
amyloid deposition, astrogliosis, microglial activation, tissue vacuolation and neuronal loss …

Numbers of neurones, synapses and axon terminals were quantified in a murine scrapie
model with severe hippocampal pyramidal cell loss, in which definite clinical scrapie is …

To elucidate the role played by the prion protein in scrapie pathogenesis, we performed
experiments with PrP27–30 isolated from scrapie‐infected hamster brains in cell culture and …

The present study investigated the relationship among PrP deposition, microglial activation,
vacuolation, and neuronal death in the hippocampus of the 301V/VM murine scrapie model …

Cultured cell lines infected with prions produce an abnormal isoform of the prion protein
(PrPSc). In order to derive cell lines producing sufficient quantities of PrPSc for most studies …

Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases
that occur in a wide variety of mammals. In humans, TSE diseases include kuru, sporadic …

We have generated lines of transgenic mice that express a mutant prion protein (PrP)
containing 14 octapeptide repeats whose human homologue is associated with an inherited …

Neuronal loss is a salient feature of prion diseases; however, its causes and mechanisms
are unclear. The possibility that it could occur through an apoptotic process has been …