Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …

Cancer cells that transit from primary tumours into the circulatory system are known as
circulating tumour cells (CTCs). These cancer cells have unique phenotypic and genotypic …

The adventitia and the outer layers of media of an atherosclerosis-prone arterial wall are
vascularized by vasa vasorum. Upon growth of an atherosclerotic lesion in the intima …

Venous thromboembolism (vte) represents a major challenge in the management of patients
with cancer. The malignant phenotype is associated with derangements in the coagulation …

Ageing of the male reproductive system is characterized by changes in the endocrine
system, hypogonadism, erectile dysfunction and proliferative disorders of the prostate gland …

Many studies have suggested a role for the members of the G 12 family of heterotrimeric G
proteins (Gα 12 and Gα 13) in oncogenesis and tumor cell growth. However, few studies …

Thrombin, the ligand of the protease-activated receptor 1 (PAR1), is a well-known stimulator
of proangiogenic responses in vascular endothelial cells (ECs), which are mediated through …

Non-HLA-directed regulatory autoantibodies (RABs) are known to target G-protein coupled
receptors (GPCRs) and thereby contribute to kidney transplant vasculopathy and failure …

A major characteristic of prostate cancer is the elevation of serum levels of prostate-specific
antigen (hK3) and hK2, which are tumor markers that correlate with advancing stages of …

Mesenchymal stem cells (MSCs) transplantation has been proposed as a promising means
for ischemic heart disease. Vascular endothelial growth factor (VEGF) has been …