Alzheimer's disease and impaired bone microarchitecture, regeneration and potential genetic links

M Zhang, S Hu, X Sun - Life, 2023 - mdpi.com
Alzheimer's Disease (AD) and osteoporosis are both age-related degenerative diseases.
Many studies indicate that these two diseases share common pathogenesis mechanisms. In …

The protective effects of osteocyte‐derived extracellular vesicles against Alzheimer's disease diminished with aging

YL Jiang, ZX Wang, XX Liu, MD Wan, YW Liu… - Advanced …, 2022 - Wiley Online Library
Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated
degenerative diseases and are strongly correlated with clinical epidemiology. However …

Mg2+-doped carbon dots synthesized based on Lycium ruthenicum in cell imaging and promoting osteogenic differentiation in vitro

Y Hou, R Zhang, H Cheng, Y Wang, Q Zhang… - Colloids and Surfaces A …, 2023 - Elsevier
The construction of biomaterials suitable for bone regeneration has been a serious
challenge in the medical field. Considering that the process of bone regeneration is difficult …

The roles of hepatokine and osteokine in liver-bone crosstalk: Advance in basic and clinical aspects

Z Li, X Wen, N Li, C Zhong, L Chen, F Zhang… - Frontiers in …, 2023 - frontiersin.org
Both the liver and bone are important secretory organs in the endocrine system. By secreting
organ factors (hepatokines), the liver regulates the activity of other organs. Similarly, bone …

Age-and sex-related differences of periodontal bone resorption, cognitive function, and immune state in APP/PS1 murine model of Alzheimer's disease

H Chen, Y Liao, X Zhang, H Shen, D Shang… - Journal of …, 2023 - Springer
Background The existence of an interconnected mechanism between cognitive disorders
and periodontitis has been confirmed by mounting evidence. However, the role of age or sex …

Interaction between ferroptosis and TNF‐α: impact in obesity‐related osteoporosis

X Chen, C Liu, R Yu, Z Gan, Z Zhang… - The FASEB …, 2023 - Wiley Online Library
The relationship of obesity and osteoporosis has been widely studied over the past years.
However, the implications of obesity for bone health remain controversial, and the …

Attenuation of Alzheimer's brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone

L Chen, L Xiong, L Yao, J Pan, E Arzola, X Zhu… - Alzheimer's research & …, 2023 - Springer
Background Alzheimer's disease (AD) and osteoporosis are two distinct diseases but often
occur in the same patient. Their relationship remains poorly understood. Studies using …

P. Gingivalis induce macrophage polarization by regulating hepcidin expression in chronic apical periodontitis

J Dou, X Chen, J Zhang, L Yang, J Lin, W Zhu… - International …, 2024 - Elsevier
Introduction Hepcidin, a central regulatory molecule of iron metabolism, is upregulated
through the IL-6/STAT3 signaling pathway in inflammatory and infectious states, contributing …

A versatile synthetic strategy for Mg-doped carbon dots derived from the traditional Chinese herb mulberry and its application in osteoblastic differentiation

Q Zhang, G Yang, L Zhang, N Li, Y Hou… - … of Photochemistry and …, 2024 - Elsevier
In this work, Mg-doped CDs were synthesized by different hydrothermal routes using the
traditional Chinese herb mulberry as the carbon source and MgCl 2· 6H 2 O as the …

[HTML][HTML] microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity

DJ Hayman, FMJ de Sousa Brito, H Lin, A Prior… - Bone, 2025 - Elsevier
MicroRNAs (miRNAs) modulate the expression of other RNA molecules. One miRNA can
target many transcripts, allowing each miRNA to play key roles in many biological pathways …