Circulating tumor DNA in B-cell lymphoma: technical advances, clinical applications, and perspectives for translational research

EM Lauer, J Mutter, F Scherer - Leukemia, 2022 - nature.com
Noninvasive disease monitoring and risk stratification by circulating tumor DNA (ctDNA)
profiling has become a potential novel strategy for patient management in B-cell lymphoma …

Prevention and management of secondary central nervous system lymphoma

S Bobillo, J Khwaja, AJM Ferreri… - Haematologica, 2022 - pmc.ncbi.nlm.nih.gov
Secondary central nervous system (CNS) lymphoma (SCNSL) is defined by the involvement
of the CNS, either at the time of initial diagnosis of systemic lymphoma or in the setting of …

Circulating tumor DNA profiling for detection, risk stratification, and classification of brain lymphomas

JA Mutter, SK Alig, MS Esfahani, EM Lauer… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Clinical outcomes of patients with CNS lymphomas (CNSLs) are remarkably
heterogeneous, yet identification of patients at high risk for treatment failure is challenging …

[HTML][HTML] How we treat primary central nervous system lymphoma

T Calimeri, S Steffanoni, F Gagliardi, A Chiara… - ESMO open, 2021 - Elsevier
Primary diffuse large B-cell (DLBCL) lymphoma of the central nervous system
(CNS)(PCNSL) is a new lymphoma entity, recognized by the 2017 WHO classification of …

Combining MYD88 L265P mutation detection and clonality determination on CSF cellular and cell‐free DNA improves diagnosis of primary CNS lymphoma

C Bravetti, M Degaud, M Armand… - British Journal of …, 2023 - Wiley Online Library
Diagnosis of primary central nervous system lymphoma (PCNSL) is challenging, and
although brain biopsy remains the gold standard, cerebrospinal fluid (CSF) constitutes a …

Molecular diagnosis of primary CNS lymphoma in 2024 using MYD88Leu265Pro and IL-10

T Calimeri, N Anzalone, MG Cangi, P Fiore… - The Lancet …, 2024 - thelancet.com
Early diagnosis is crucial for the successful treatment of primary CNS lymphoma (PCNSL), a
rapidly progressing tumour. Suspicion raised on brain MRI must be confirmed by a …

[HTML][HTML] Is liquid biopsy mature enough for the diagnosis of Alzheimer's disease?

X Gong, H Zhang, X Liu, Y Liu, J Liu… - Frontiers in Aging …, 2022 - frontiersin.org
The preclinical diagnosis and clinical practice for Alzheimer's disease (AD) based on liquid
biopsy have made great progress in recent years. As liquid biopsy is a fast, low-cost, and …

Liquid biopsy of cerebrospinal fluid for MYD88 L265P mutation is useful for diagnosis of central nervous system lymphoma

Y Yamagishi, N Sasaki, Y Nakano, Y Matushita… - Cancer …, 2021 - Wiley Online Library
The current standard of diagnosing central nervous system (CNS) lymphoma is stereotactic
biopsy, however the procedure has a risk of surgical complication. Liquid biopsy of the CSF …

Liquid biopsy and other non-invasive diagnostic measures in PCNSL

A Baraniskin, R Schroers - Cancers, 2021 - mdpi.com
Simple Summary Primary central nervous system lymphoma (PCNSL) is an uncommon
disease accounting for around 3% of primary CNS tumors. PCNSL exhibits aggressive …

Clinical applications of circulating tumor DNA in central nervous system lymphoma

AK Foerster, EM Lauer, F Scherer - Seminars in Hematology, 2023 - Elsevier
Detection and characterization of circulating tumor DNA (ctDNA) in body fluids has the
potential to revolutionize management of patients with lymphoma. Minimal access to …