Wearable electrochemical sensors for the monitoring and screening of drugs

H Teymourian, M Parrilla, JR Sempionatto… - ACS …, 2020 - ACS Publications
Wearable electrochemical sensors capable of noninvasive monitoring of chemical markers
represent a rapidly emerging digital-health technology. Recent advances toward wearable …

Wearable electrochemical biosensors in North America

J Min, JR Sempionatto, H Teymourian, J Wang… - Biosensors and …, 2021 - Elsevier
Tremendous research and commercialization efforts around the world are focused on
developing novel wearable electrochemical biosensors that can noninvasively and …

Wearable microneedle-based electrochemical aptamer biosensing for precision dosing of drugs with narrow therapeutic windows

S Lin, X Cheng, J Zhu, B Wang, D Jelinek, Y Zhao… - Science …, 2022 - science.org
Therapeutic drug monitoring is essential for dosing pharmaceuticals with narrow therapeutic
windows. Nevertheless, standard methods are imprecise and involve invasive/resource …

Microneedle aptamer-based sensors for continuous, real-time therapeutic drug monitoring

Y Wu, F Tehrani, H Teymourian, J Mack… - Analytical …, 2022 - ACS Publications
The ability to continuously monitor the concentration of specific molecules in the body is a
long-sought goal of biomedical research. For this purpose, interstitial fluid (ISF) was …

Lab under the skin: microneedle based wearable devices

H Teymourian, F Tehrani, K Mahato… - Advanced healthcare …, 2021 - Wiley Online Library
While the current smartwatches and cellphones can readily track mobility and vital signs, a
new generation of wearable devices is rapidly developing to enable users to monitor their …

Real-Time, In Vivo Molecular Monitoring Using Electrochemical Aptamer Based Sensors: Opportunities and Challenges

AM Downs, KW Plaxco - ACS sensors, 2022 - ACS Publications
The continuous, real-time measurement of specific molecules in situ in the body would
greatly improve our ability to understand, diagnose, and treat disease. The vast majority of …

Electrochemical aptamer-based sensors for improved therapeutic drug monitoring and high-precision, feedback-controlled drug delivery

P Dauphin-Ducharme, K Yang, N Arroyo-Currás… - ACS …, 2019 - ACS Publications
The electrochemical aptamer-based (E-AB) sensing platform appears to be a convenient
(rapid, single-step, and calibration-free) and modular approach to measure concentrations …

Elucidating the mechanisms underlying the signal drift of electrochemical aptamer-based sensors in whole blood

KK Leung, AM Downs, G Ortega, M Kurnik… - ACS …, 2021 - ACS Publications
The ability to monitor drugs, metabolites, hormones, and other biomarkers in situ in the body
would greatly advance both clinical practice and biomedical research. To this end, we are …

Optimizing antimicrobial use: challenges, advances and opportunities

TM Rawson, RC Wilson, D O'Hare, P Herrero… - Nature Reviews …, 2021 - nature.com
An optimal antimicrobial dose provides enough drug to achieve a clinical response while
minimizing toxicity and development of drug resistance. There can be considerable …

Real-Time, Seconds-resolved measurements of plasma methotrexate in situ in the living body

A Chamorro-Garcia, J Gerson, C Flatebo, L Fetter… - ACS …, 2022 - ACS Publications
Dose-limiting toxicity and significant patient-to-patient pharmacokinetic variability often
render it difficult to achieve the safe and effective dosing of drugs. This is further …