[4+ 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of
many structurally complex natural products. A relatively small collection of enzymes from …

Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide
synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed …

Cycloaddition reactions are among the most widely used reactions in chemical synthesis.
Nature achieves these cyclization reactions with a variety of enzymes, including Diels …

Covering: 2011 to July 2017. Spiroketal (spiroacetal), a common moiety in numerous natural
products, drugs and functional molecules, has been a central topic in organic chemistry for a …

The trans-decalin structure formed by intramolecular Diels–Alder cycloaddition is widely
present among bioactive natural products isolated from fungi. We elucidated the concise …

Summary The Diels-Alder [4+ 2] cycloaddition reaction is one of the most powerful and
elegant organic synthesis methods for forming 6-membered molecules and has been known …

Thiopeptide antibiotics are a class of typical ribosomally synthesized and post-translationally
modified peptides (RiPPs) with complex chemical structures that are difficult to construct via …

Abstract Long sought after [4+ 2] cyclases have sprouted up in numerous biosynthetic
pathways in recent years, raising hopes for biocatalytic solutions to cycloaddition catalysis …

Herpotrichones A and B (1 and 2), two intermolecular [4+ 2] adducts with an unprecedented
pentacyclic 6/6/6/6/3 skeleton, were isolated from Herpotrichia sp. SF09, an isopod …

The decarbonylation reaction has been developed significantly in organic chemistry as an
effective approach to various synthetic applications, but enzymatic precedents for this …