The protein corona from nanomedicine to environmental science

M Mahmoudi, MP Landry, A Moore… - Nature Reviews Materials, 2023 - nature.com
The protein corona spontaneously develops and evolves on the surface of nanoscale
materials when they are exposed to biological environments, altering their physiochemical …

A materials-science perspective on tackling COVID-19

Z Tang, N Kong, X Zhang, Y Liu, P Hu, S Mou… - Nature Reviews …, 2020 - nature.com
The ongoing SARS-CoV-2 pandemic highlights the importance of materials science in
providing tools and technologies for antiviral research and treatment development. In this …

Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery

M Hu, X Li, Z You, R Cai, C Chen - Advanced Materials, 2024 - Wiley Online Library
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

The biomolecular corona of lipid nanoparticles for gene therapy

V Francia, RM Schiffelers, PR Cullis… - Bioconjugate …, 2020 - ACS Publications
Gene therapy holds great potential for treating almost any disease by gene silencing, protein
expression, or gene correction. To efficiently deliver the nucleic acid payload to its target …

'Passive'nanoparticles for organ-selective systemic delivery: design, mechanism and perspective

L Fu, Y Zhang, RA Farokhzad, BB Mendes… - Chemical Society …, 2023 - pubs.rsc.org
Nanotechnology has shown tremendous success in the drug delivery field for more effective
and safer therapy, and has recently enabled the clinical approval of RNA medicine, a new …

Controlling the biodistribution and clearance of nanomedicines

H Cabral, J Li, K Miyata, K Kataoka - Nature Reviews Bioengineering, 2024 - nature.com
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …

Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across …

G Vergauwen, J Tulkens, C Pinheiro… - Journal of …, 2021 - Wiley Online Library
Separating extracellular vesicles (EV) from blood plasma is challenging and complicates
their biological understanding and biomarker development. In this study, we fractionate …

Synthetic cells in biomedical applications

W Sato, T Zajkowski, F Moser… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Synthetic cells are engineered vesicles that can mimic one or more salient features of life.
These features include directed localization, sense‐and‐respond behavior, gene …

Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo

G Arias-Alpizar, L Kong, RC Vlieg, A Rabe… - Nature …, 2020 - nature.com
Surface charge plays a fundamental role in determining the fate of a nanoparticle, and any
encapsulated contents, in vivo. Herein, we describe, and visualise in real time, light …

Spotlight on the protein corona of liposomes

N Onishchenko, D Tretiakova, E Vodovozova - Acta biomaterialia, 2021 - Elsevier
Although an established drug delivery platform, liposomes have not fulfilled their true
potential. In the body, interactions of liposomes are mediated by the layer of plasma proteins …