The zebrafish is a recent addition to animal models of human cancer, and studies using this
model are rapidly contributing major insights. Zebrafish develop cancer spontaneously, after …

Since its first splash 30 years ago, the use of the zebrafish model has been extended from a
tool for genetic dissection of early vertebrate development to the functional interrogation of …

The development of facile forward and reverse genetic approaches has propelled the
deconvolution of gene function in biology. While the origins of these techniques reside in the …

To detect targeted antileukemia agents we have designed a novel, high-content in vivo
screen using genetically engineered, T-cell reporting zebrafish. We exploited the …

Self-renewal is a feature of cancer and can be assessed by cell transplantation into immune-
compromised or immune-matched animals. However, studies in zebrafish have been …

For the last three decades significant parts of national science budgets, and international
and private funding worldwide, have been dedicated to cancer research. This has resulted …

Regulatory T (T reg) cells are a specialized sublineage of T lymphocytes that suppress
autoreactive T cells. Functional studies of T reg cells in vitro have defined multiple …

Tumor transplant studies are important tools for studying cancer biology in a model
organism. Transplantation is especially important for assaying tumor cell malignancy and …

Zebrafish (Danio rerio) is an excellent model to study a wide diversity of human cancers. In
this review, we provide an overview of the genetic and reverse genetic toolbox allowing the …

In the last 30 years, the zebrafish has become a widely used model organism for research
on vertebrate development and disease. Through a powerful combination of genetics and …