Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I
MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II …

Although they are often exploited to facilitate the expression and purification of recombinant
proteins, every affinity tag, whether large or small, has the potential to interfere with the …

Since the first application of the surface plasmon resonance (SPR) phenomenon for sensing
almost two decades ago, this method has made great strides both in terms of …

The interaction between the T‐cell receptor (TCR) and its peptide–major histocompatibility
complex (pepMHC) ligand plays a critical role in determining the activity and specificity of …

The CD1 family of major histocompatibility complex (MHC)-like molecules specializes in
presenting lipid and glycolipid antigens to α/β T lymphocytes, but little is known about the …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

▪ Abstract Over the past decade, key protein interactions contributing to T cell antigen
recognition have been characterized in molecular detail. These have included interactions …

The T cell receptor (TCR) inherently has dual specificity. T cells must recognize self-antigens
in the thymus during maturation and then discriminate between foreign pathogens in the …

The relative roles of CD8, TCR: pepMHC affinity, and TCR: pepMHC dissociation rate in T
cell activation have remained controversial. To determine the relationships among these …

Multimeric soluble MHC class II molecules stably occupied with covalently attached peptides
bind with appropriate specificity to T cell hybridomas and T cells from T cell receptor …