For almost 70 years, calorie restriction has been known to extend life span. Despite the
extensive physiological characterization of this dietary regimen, the molecular basis for the …

The goal of this short review is to summarize recent data on gastrointestinal changes with
aging, focusing on gastrointestinal motility disorders, and mucosal variations. First of all, this …

Although many hypotheses have been proposed to explain the aging process, the exact
mechanisms are not well defined. Recent accumulating evidence indicates that …

Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and reduced
insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and …

This article describes changes in the basic digestive functions (motility, secretion,
intraluminal digestion, absorption) that occur during aging. Elderly individuals frequently …

The gut barrier is the first line of defense against harmful substances and pathogens in the
intestinal tract. The balance of proliferation and apoptosis of intestinal epithelial cells (IECs) …

Background & Aims: Our understanding of the intestinotropic actions of glucagon-like
peptide-2 (GLP-2) 1–33 is based on pharmacologic studies involving exogenous …

To investigate the importance of body fuel depletion on gut rehabilitation after food
deprivation, we compared the kinetics of jejunal mucosa alteration and restoration in rats …

Thermal injury has been shown to alter gut epithelium and heart myocyte homeostasis by
inducing programmed cell death. The effect of thermal injury on hepatocyte apoptosis and …

The intestine is key for nutrient absorption and for interactions between the microbiota and
its host. Therefore, the intestinal response to caloric restriction (CR) is thought to be more …