The role of tumor necrosis factor-alpha in the pathogenesis and treatment of nonalcoholic fatty liver disease

ID Vachliotis, SA Polyzos - Current obesity reports, 2023 - Springer
Abstract Purpose of Review To summarize experimental and clinical evidence on the
association between tumor necrosis factor-α (TNF-α) and nonalcoholic fatty liver disease …

New insights into the pathogenesis of non-alcoholic fatty liver disease: gut-derived lipopolysaccharides and oxidative stress

D Ferro, F Baratta, D Pastori, N Cocomello, A Colantoni… - Nutrients, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. The intricate NAFLD pathogenesis is summarized by the multiple-hits …

[PDF][PDF] Increased liver localization of lipopolysaccharides in human and experimental NAFLD

G Carpino, M Del Ben, D Pastori, R Carnevale… - …, 2020 - Wiley Online Library
Background and Aims Lipopolysaccharides (LPS) is increased in nonalcoholic fatty liver
disease (NAFLD), but its relationship with liver inflammation is not defined. Approach and …

Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives

H Hu, A Lin, M Kong, X Yao, M Yin, H Xia, J Ma… - Journal of …, 2020 - Springer
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of dysregulated lipid
and glucose metabolism, which is often associated with obesity, dyslipidemia and insulin …

[PDF][PDF] The use of rifaximin in patients with cirrhosis

P Caraceni, V Vargas, E Solà, C Alessandria… - …, 2021 - Wiley Online Library
Rifaximin is an oral nonsystemic antibiotic with minimal gastrointestinal absorption and
broad‐spectrum antibacterial activity covering both gram‐positive and gram‐negative …

[HTML][HTML] Endotoxins and non-alcoholic fatty liver disease

T Kessoku, T Kobayashi, K Imajo, K Tanaka… - Frontiers in …, 2021 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. It occurs with a prevalence of up to 25%, of which 10–20% cases progress to …

The epidemiology, risk profiling and diagnostic challenges of nonalcoholic fatty liver disease

U Iqbal, BJ Perumpail, D Akhtar, D Kim, A Ahmed - Medicines, 2019 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of liver damage
from the more prevalent (75%–80%) and nonprogressive nonalcoholic fatty liver (NAFL) …

Microbial metabolites: critical regulators in NAFLD

X Dai, H Hou, W Zhang, T Liu, Y Li, S Wang… - Frontiers in …, 2020 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease
throughout the world. The relationship between gut microbiota and NAFLD has been …

Molecular and cellular mediators of the gut-liver axis in the progression of liver diseases

A Bruneau, J Hundertmark, A Guillot, F Tacke - Frontiers in Medicine, 2021 - frontiersin.org
The gut-liver axis covers the bidirectional communication between the gut and the liver, and
thus includes signals from liver-to-gut (eg, bile acids, immunoglobulins) and from gut-to-liver …

Gut microbiome determines therapeutic effects of OCA on NAFLD by modulating bile acid metabolism

J Liu, J Sun, J Yu, H Chen, D Zhang, T Zhang… - npj Biofilms and …, 2023 - nature.com
Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease, had no
approved pharmacological agents yet. Obeticholic acid (OCA), a novel bile acid derivative …