Mania-related effects on structural brain changes in bipolar disorder–a narrative review of the evidence

C Abé, B Liberg, AL Klahn, P Petrovic, M Landén - Molecular Psychiatry, 2023 - nature.com
Cross-sectional neuroimaging studies show that bipolar disorder is associated with
structural brain abnormalities, predominantly observed in prefrontal and temporal cortex …

The effect of polygenic risk scores for major depressive disorder, bipolar disorder and schizophrenia on morphological brain measures: a systematic review of the …

G Cattarinussi, G Delvecchio, F Sambataro… - Journal of affective …, 2022 - Elsevier
Background Major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia
(SCZ) share clinical features and genetic bases. Magnetic Resonance Imaging (MRI) …

Using structural MRI to identify bipolar disorders–13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group

A Nunes, HG Schnack, CRK Ching, I Agartz… - Molecular …, 2020 - nature.com
Bipolar disorders (BDs) are among the leading causes of morbidity and disability. Objective
biological markers, such as those based on brain imaging, could aid in clinical management …

Brain age in early stages of bipolar disorders or schizophrenia

T Hajek, K Franke, M Kolenic, J Capkova… - Schizophrenia …, 2019 - academic.oup.com
Background The greater presence of neurodevelopmental antecedants may differentiate
schizophrenia from bipolar disorders (BD). Machine learning/pattern recognition allows us to …

[HTML][HTML] The association between familial risk and brain abnormalities is disease specific: an ENIGMA-relatives study of schizophrenia and bipolar disorder

SM De Zwarte, RM Brouwer, I Agartz, M Alda… - Biological …, 2019 - Elsevier
Background Schizophrenia and bipolar disorder share genetic liability, and some structural
brain abnormalities are common to both conditions. First-degree relatives of patients with …

Evaluating endophenotypes for bipolar disorder

R Guglielmo, KW Miskowiak, G Hasler - International Journal of Bipolar …, 2021 - Springer
Background Phenotypic heterogeneity is a major impediment to the elucidation of the
neurobiology and genetics of bipolar disorder. Endophenotype could help in reducing …

Functional alterations in patients with bipolar disorder and their unaffected first-degree relatives: insight from genetic, epidemiological, and neuroimaging data

H Zhang, J Chen, Y Fang - Neuropsychiatric Disease and …, 2023 - Taylor & Francis
Bipolar disorder (BD) profoundly affects cognitive and psychosocial functioning, leading to a
significant illness burden on patients and their families. Genetic factors are predominant in …

Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder

S Hesam-Shariati, BJ Overs, G Roberts, C Toma… - Translational …, 2022 - nature.com
Environmental factors contribute to risk of bipolar disorder (BD), but how environmental
factors impact the development of psychopathology within the context of elevated genetic …

Associations between parental mood and anxiety psychopathology and offspring brain structure: A scoping review

JVA Kemp, E Bernier, C Lebel… - Clinical Child and Family …, 2022 - Springer
A family history of mood and anxiety disorders is one of the most well-established risk factors
for these disorders in offspring. A family history of these disorders has also been linked to …

Changes in white matter microstructure predict lithium response in adolescents with bipolar disorder

V Kafantaris, L Spritzer, V Doshi, E Saito… - Bipolar …, 2017 - Wiley Online Library
Objectives To investigate whether response to lithium treatment in pediatric bipolar disorder
can be predicted by changes in white matter microstructure in key cortico‐limbic tracts …