Brugada Syndrome: Report of the Second Consensus Conference: Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association

C Antzelevitch, P Brugada, M Borggrefe, J Brugada… - Circulation, 2005 - Am Heart Assoc
Since its introduction as a clinical entity in 1992, the Brugada syndrome has progressed
from being a rare disease to one that is second only to automobile accidents as a cause of …

Genetics of sudden cardiac death

CR Bezzina, N Lahrouchi, SG Priori - Circulation research, 2015 - Am Heart Assoc
Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an important
cause of mortality in the general population. Genetic studies conducted during the past 20 …

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

CR Bezzina, J Barc, Y Mizusawa, CA Remme… - Nature …, 2013 - nature.com
Brugada syndrome is a rare cardiac arrhythmia disorder, causally related to SCN5A
mutations in around 20% of cases,,. Through a genome-wide association study of 312 …

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

JD Kapplinger, DJ Tester, M Alders, B Benito, M Berthet… - Heart rhythm, 2010 - Elsevier
BACKGROUND: Brugada syndrome (BrS) is a common heritable channelopathy. Mutations
in the SCN5A-encoded sodium channel (BrS1) culminate in the most common genotype …

Task force on sudden cardiac death of the European Society of Cardiology

SG Priori, E Aliot, C Blomstrom-Lundqvist… - European heart …, 2001 - academic.oup.com
The members of the Task Force on Sudden Death dedicate this paper to the memory of our
former friend and colleague, Professor Ronald WF Campbell. Ronnie spent his life working …

Proposed diagnostic criteria for the Brugada syndrome: consensus report

AAM Wilde, C Antzelevitch, M Borggrefe, J Brugada… - Circulation, 2002 - Am Heart Assoc
in a superior intercostal space in individuals with high clinical suspicion (aborted sudden
cardiac death victims, family members of patients with Brugada syndrome) may also …

Natural history of Brugada syndrome: insights for risk stratification and management

SG Priori, C Napolitano, M Gasparini, C Pappone… - Circulation, 2002 - Am Heart Assoc
Background—Treatment of patients with Brugada syndrome is complicated by the
incomplete information on the natural history of the disease related to the small number of …

Tpeak-Tend and Tpeak-Tend dispersion as risk factors for ventricular tachycardia/ventricular fibrillation in patients with the Brugada syndrome

J Castro Hevia, C Antzelevitch… - Journal of the American …, 2006 - jacc.org
Objectives: Our objective in this study was to evaluate Tpeak-Tend interval (Tp-e) and other
electrocardiographic parameters as risk factors for recurrence of life-threatening cardiac …

Long-Term Follow-Up of Individuals With the Electrocardiographic Pattern of Right Bundle-Branch Block and ST-Segment Elevation in Precordial Leads V1 to V3

J Brugada, R Brugada, C Antzelevitch, J Towbin… - Circulation, 2002 - Am Heart Assoc
Background—The electrocardiographic pattern of right bundle-branch block with ST-
segment elevation in leads V1 to V3 is increasingly recognized among patients who have …

Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans

H Watanabe, TT Koopmann… - The Journal of …, 2008 - Am Soc Clin Investig
Brugada syndrome is a genetic disease associated with sudden cardiac death that is
characterized by ventricular fibrillation and right precordial ST segment elevation on ECG …