Heterocyclic moieties form a major part of organic chemistry as they are widely distributed in
nature and have wide scale practical applications ranging from extensive clinical use to …

Liver cancer is one of the most common causes of cancer death worldwide. In recent years,
substantial progress has been made in the development of systemic therapies, but there is …

Background: Several pre-clinical and clinical reports suggest that HIV-1 protease inhibitors,
in addition to the antiretroviral properties, possess pleiotropic pharmacological effects …

Nowadays there is not an effective drug for the treatment of infections caused by human
adenovirus (HAdV) which supposes a clinical challenge, especially for paediatric and …

Over the years, human adenovirus (HAdV) has progressively been recognized as a
significant viral pathogen. Traditionally associated with self-limited respiratory …

Here, we report the synthesis, enzyme inhibition and structure–activity relationship studies of
a new potent class of HIV-1 protease inhibitors, which contain a pseudo-symmetric …

The Virus HIV-1 infection still represents a serious disease even if actually it is transformed
in chronic pathology. Considering the crucial role of the enzyme Protease in life cycle of HIV …

A total synthesis of four flavans with a furan ring in different positions (1–4) was achieved
successfully. The flavan was synthesized from flavanone by reduction and followed by …

The Virus HIV-1 infection still represents a serious disease even if actually it is transformed
in chronic pathology. Considering the crucial role of the enzyme Protease in life cycle of HIV …