Following their discovery at the end of the 20th century, extracellular vesicles (EVs) ranging
from 50-1,000 nm have proven to be paramount in the progression of many cancers …

Myeloproliferative neoplasms (MPNs), a group of malignant hematological disorders, occur
as a consequence of somatic mutations in the hematopoietic stem cell compartment and …

Myeloproliferative neoplasms (MPNs) are rare, clonal disorders of the hematopoietic stem
cell in which an uncontrolled proliferation of terminally differentiated myeloid cells is noted …

The bone marrow (BM) niche is the spatial structure within the intra-trabecular spaces of
spongious bones and of the cavity of long bones where adult haematopoietic stem cells …

Myeloid neoplasms arise from malignant primitive cells, which exhibit growth advantage
within the bone marrow microenvironment (BMM). The interaction between these malignant …

Myeloproliferative Neoplasms (MPN) are acquired clonal disorders of the hematopoietic
stem cells and include Essential Thrombocythemia, Polycythemia Vera and Myelofibrosis …

Polycythemia Vera (PV) is a myeloproliferative neoplasm with increased risk of thrombosis
and progression to myelofibrosis. Chronic inflammation is commonly observed in …

Blood cancers are a heterogeneous group of disorders including leukemia, multiple
myeloma, and lymphoma. They may derive from the clonal evolution of the hemopoietic …

Extracellular vesicles (EVs) have emerged as important mediators of homeostasis, immune
modulation and intercellular communication. They are released by every cell of the human …

There is a general and solid theoretical framework to explain how the interplay between
natural selection and gene flow affects local adaptation. Yet, to what extent coexisting …