Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …

Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

Existing concepts and models for glucose‐stimulated insulin secretion (GSIS) are
overviewed and a newer perspective has been formulated toward the physiological …

Competition for respiration between substrates in animal tissues has been known for at least
80 Years. The most important interaction, quantitatively is between glucose and fatty acids …

Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

The concept of glucolipotoxicity refers to the combined, deleterious effects of elevated
glucose, and fatty acid levels on pancreatic beta-cell function and survival. Significant …

The intracellular concentration of free unbound acyl-CoA esters is tightly controlled by
feedback inhibition of the acyl-CoA synthetase and is buffered by specific acyl-CoA binding …

Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …

Previous studies in rat islets have suggested that anaplerosis plays an important role in the
regulation of pancreatic β cell function and growth. However, the relative contribution of islet …

β-Cells possess inherent mechanisms to adapt to overnutrition and the prevailing
concentrations of glucose, fatty acids, and other fuels to maintain glucose homeostasis …