HIV evolution and diversity in ART-treated patients
Characterizing HIV genetic diversity and evolution during antiretroviral therapy (ART)
provides insights into the mechanisms that maintain the viral reservoir during ART. This …
provides insights into the mechanisms that maintain the viral reservoir during ART. This …
Phylogenetic inferences on HIV-1 transmission: implications for the design of prevention and treatment interventions
In 30 years, the HIV-1/AIDS pandemic has evolved into an increasingly complex disease
composed of multiple epidemics, each influenced by a complex array of biological …
composed of multiple epidemics, each influenced by a complex array of biological …
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody
DR Burton, AJ Hessell, BF Keele… - Proceedings of the …, 2011 - National Acad Sciences
To guide vaccine design, we assessed whether human monoclonal antibodies (MAbs) b12
and b6 against the CD4 binding site (CD4bs) on HIV-1 gp120 and F240 against an …
and b6 against the CD4 binding site (CD4bs) on HIV-1 gp120 and F240 against an …
Identifying recombination hot spots in the HIV-1 genome
ABSTRACT HIV-1 infection is characterized by the rapid generation of genetic diversity that
facilitates viral escape from immune selection and antiretroviral therapy. Despite …
facilitates viral escape from immune selection and antiretroviral therapy. Despite …
Highly divergent patterns of genetic diversity and evolution in proviral quasispecies from HIV controllers
SSD de Azevedo, DG Caetano, FH Côrtes… - Retrovirology, 2017 - Springer
Background Ongoing intra-host HIV-1 evolution has been shown in individuals that naturally
suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma …
suppress the viremia to low levels (HIV controllers) by the analysis of the RNA in plasma …
Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events
GQ Del Prete, H Park, CM Fennessey, C Reid… - Journal of …, 2014 - Am Soc Microbiol
Following mucosal human immunodeficiency virus type 1 transmission, systemic infection is
established by one or only a few viral variants. Modeling single-variant, mucosal …
established by one or only a few viral variants. Modeling single-variant, mucosal …
Recombination-mediated escape from primary CD8+ T cells in acute HIV-1 infection
AJ Ritchie, F Cai, NMG Smith, S Chen, H Song… - Retrovirology, 2014 - Springer
Background A major immune evasion mechanism of HIV-1 is the accumulation of non-
synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition …
synonymous mutations in and around T cell epitopes, resulting in loss of T cell recognition …
Phylogenetic relatedness of circulating HIV-1C variants in Mochudi, Botswana
Background Determining patterns of HIV transmission is increasingly important for the most
efficient use of modern prevention interventions. HIV phylogeny can provide a better …
efficient use of modern prevention interventions. HIV phylogeny can provide a better …
Accurate predictions of population-level changes in sequence and structural properties of HIV-1 Env using a volatility-controlled diffusion model
O DeLeon, H Hodis, Y O'Malley, J Johnson… - PLoS …, 2017 - journals.plos.org
The envelope glycoproteins (Envs) of HIV-1 continuously evolve in the host by random
mutations and recombination events. The resulting diversity of Env variants circulating in the …
mutations and recombination events. The resulting diversity of Env variants circulating in the …
Recombination enhances HIV-1 envelope diversity by facilitating the survival of latent genomic fragments in the plasma virus population
TT Immonen, JM Conway… - PLoS computational …, 2015 - journals.plos.org
HIV-1 is subject to immune pressure exerted by the host, giving variants that escape the
immune response an advantage. Virus released from activated latent cells competes against …
immune response an advantage. Virus released from activated latent cells competes against …