Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Amino acids as mediators of metabolic cross talk between host and pathogen

W Ren, R Rajendran, Y Zhao, B Tan, G Wu… - Frontiers in …, 2018 - frontiersin.org
The interaction between host and pathogen decidedly shapes the outcome of an infection,
thus understanding this interaction is critical to the treatment of a pathogen-induced …

Leishmania exosomes/extracellular vesicles containing GP63 are essential for enhance cutaneous leishmaniasis development upon co-inoculation of Leishmania …

A da Silva Lira Filho, EF Fajardo, KP Chang… - Frontiers in cellular …, 2022 - frontiersin.org
Protozoan parasites of the genus Leishmania are transmitted by the bite of infected sand
flies leading to a wide range of diseases called leishmaniasis. Recently, we demonstrated …

The pathogenicity and virulence of Leishmania-interplay of virulence factors with host defenses

AK Gupta, S Das, M Kamran, SA Ejazi, N Ali - Virulence, 2022 - Taylor & Francis
Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …

The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids

L Marchese, JF Nascimento, FS Damasceno… - Pathogens, 2018 - mdpi.com
Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus
Leishmania, form a group of flagellated protists that threaten human health. These …

Leishmania Hijacks Myeloid Cells for Immune Escape

M Martínez-López, M Soto, S Iborra… - Frontiers in …, 2018 - frontiersin.org
Protozoan parasites of the Leishmania genus are the causative agents of leishmaniasis, a
group of neglected tropical diseases whose clinical manifestations vary depending on the …

Th1-Th2 cross-regulation controls early Leishmania infection in the skin by modulating the size of the permissive monocytic host cell reservoir

MB Carneiro, ME Lopes, LS Hohman, A Romano… - Cell host & …, 2020 - cell.com
The impact of T helper (Th) 1 versus Th2 immunity on intracellular infections is attributed to
classical versus alternative activation of macrophages leading to resistance or susceptibility …

Leishmania Spp-Host Interaction: There Is Always an Onset, but Is There an End?

F Conceição-Silva, FN Morgado - Frontiers in cellular and infection …, 2019 - frontiersin.org
For a long time Leishmaniasis had been considered as a neglected tropical disease.
Recently, it has become a priority in public health all over the world for different aspects such …

Natural Products That Target the Arginase in Leishmania Parasites Hold Therapeutic Promise

NS Carter, BD Stamper, F Elbarbry, V Nguyen, S Lopez… - Microorganisms, 2021 - mdpi.com
Parasites of the genus Leishmania cause a variety of devastating and often fatal diseases in
humans worldwide. Because a vaccine is not available and the currently small number of …

Arginase and its mechanisms in Leishmania persistence

G Pessenda, JS da Silva - Parasite immunology, 2020 - Wiley Online Library
Leishmaniasis is a neglected infectious disease with clinical presentations ranging from
asymptomatic or mild symptoms to chronic infection and eventual death. The mechanisms of …