Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …

Chronic leg ulcers affect 1–2% of the general population and are related to increased
morbidity and health costs. Staphylococcus aureus and Pseudomonas aeruginosa are the …

Hepatic ischemia reperfusion injury (IRI) is not only a pathophysiological process involving
the liver, but also a complex systemic process affecting multiple tissues and organs. Hepatic …

Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …

Chronic venous disease (CVD) is a common venous disorder of the lower extremities. CVD
can be manifested as varicose veins (VVs), with dilated and tortuous veins, dysfunctional …

Wound healing, especially diabetic ones, is a relevant clinical problem, so it is not surprising
that surgical procedures are often needed. To overcome invasive procedures, several …

Skin tears represent a common condition of traumatic wounds, which may be encountered in
some categories of individuals at the extremes of age, such as infants and the elderly …

Lower-extremity veins have efficient wall structure and function and competent valves that
permit upward movement of deoxygenated blood toward the heart against hydrostatic …

Introduction Chronic venous disease (CVD) is a common condition associated with valvular
dysfunction, venous hypertension and endothelial inflammation. Sulodexide facilitates the …

The veins of the lower extremity are equipped with efficient wall, contractile vascular smooth
muscle (VSM), and competent valves in order to withstand the high venous hydrostatic …