Clonal hematopoiesis (CH) is an age-related process whereby hematopoietic stem and
progenitor cells (HSPCs) acquire mutations that lead to a proliferative advantage and clonal …

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by the selective
expansion of hematopoietic stem and progenitor cells (HSPCs) carrying somatic mutations …

Chronic low-grade inflammation observed in older adults, termed inflammaging, is a
common feature underlying a multitude of aging-associated maladies including a decline in …

Clonal hematopoiesis (CH) is more common in older persons and has been associated with
an increased risk of hematological cancers and cardiovascular diseases. The most common …

Somatic variants accumulate in all organs with age, with a positive selection of clonal
populations that provide a fitness advantage during times of heightened cellular stress …

The age‐associated mutational state of clonal haematopoiesis (CH) is linked to multiple
adverse health outcomes. As higher risk CH can lead to progressive neoplastic or vascular …

In myelodysplastic syndromes (MDS), the IL-1β pathway is upregulated, and previous
studies using mouse models of founder MDS mutations demonstrated that it enhances …

Inflammation is a key driver of the progression of pre-leukemic myeloid conditions, such as
clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of …

Clonal hematopoiesis (CH) is a condition in which hematopoietic stem cells (HSCs) acquire
mutations seen in leukemia. While individuals with CH generally do not show signs of …

Erythropoiesis is initiated with the transformation of multipotent hematopoietic stem cells into
committed erythroid progenitor cells in the erythroblastic islands of the bone marrow in …