Cholesterol biosynthesis: a mechanistic overview
NM Cerqueira, EF Oliveira, DS Gesto… - Biochemistry, 2016 - ACS Publications
Cholesterol is an essential component of cell membranes and the precursor for the
synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially …
synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially …
Structural and biochemical perspectives in plant isoprenoid biosynthesis
The isoprenoid family represents one of the most ancient and widespread classes of
structurally and functionally rich biomolecules known to man. Although these natural …
structurally and functionally rich biomolecules known to man. Although these natural …
Discovery of a metabolic alternative to the classical mevalonate pathway
Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA)
metabolic pathway clinically modulated using statins. Curiously, two components of the MVA …
metabolic pathway clinically modulated using statins. Curiously, two components of the MVA …
Evidence of a novel mevalonate pathway in archaea
Isoprenoids make up a remarkably diverse class of more than 25000 biomolecules that
include familiar compounds such as cholesterol, chlorophyll, vitamin A, ubiquinone, and …
include familiar compounds such as cholesterol, chlorophyll, vitamin A, ubiquinone, and …
Silver complex of salicylic acid and its hydrogel-cream in wound healing chemotherapy
MEK Stathopoulou, CN Banti, N Kourkoumelis… - Journal of inorganic …, 2018 - Elsevier
The known metallotherapeutic [Ag (salH)] 2 (AGSAL-1) of salicylic acid (salH 2), was used
for the development of new efficient silver based material for wounds healing. AGSAL-1 was …
for the development of new efficient silver based material for wounds healing. AGSAL-1 was …
Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an …
JC VanNice, DA Skaff, A Keightley, JK Addo… - Journal of …, 2014 - Am Soc Microbiol
Mevalonate (MVA) metabolism provides the isoprenoids used in archaeal lipid biosynthesis.
In synthesis of isopentenyl diphosphate, the classical MVA pathway involves …
In synthesis of isopentenyl diphosphate, the classical MVA pathway involves …
2, 3-Disubstituted-1, 4-naphthoquinones containing an arylamine with trifluoromethyl group: synthesis, biological evaluation, and computational study
Antibacterial and antifungal organic compounds are becoming increasingly important for
biomedical applications. This study deals with the synthesis, characterization of structures, in …
biomedical applications. This study deals with the synthesis, characterization of structures, in …
Enzymatic decarboxylation—an emerging reaction for chemicals production from renewable resources
Decarboxylases are very useful tools for the defunctionalization of organic molecules under
very mild reaction conditions. They have been applied for the synthesis of alcohols …
very mild reaction conditions. They have been applied for the synthesis of alcohols …
High-throughput enzyme screening platform for the IPP-bypass mevalonate pathway for isopentenol production
A Kang, CW Meadows, N Canu, JD Keasling… - Metabolic …, 2017 - Elsevier
Abstract Isopentenol (or isoprenol, 3-methyl-3-buten-1-ol) is a drop-in biofuel and a
precursor for commodity chemicals such as isoprene. Biological production of isopentenol …
precursor for commodity chemicals such as isoprene. Biological production of isopentenol …
An adaptation to life in acid through a novel mevalonate pathway
Extreme acidophiles are capable of growth at pH values near zero. Sustaining life in acidic
environments requires extensive adaptations of membranes, proton pumps, and DNA repair …
environments requires extensive adaptations of membranes, proton pumps, and DNA repair …