During the past ten years, circulating tumour cells (CTCs) have received enormous attention
as new biomarkers and the subject of basic research. Although CTCs are already used in …

To investigate whether the tumor suppressor gene PTEN affects the activity of the androgen
receptor (AR), we monitored the expression of the apoptotic gene HA-Bax (inserted in an …

Abstract Purpose: The CellSearch system (Veridex, Warren, NJ) is designed to enrich and
enumerate circulating tumor cells (CTCs) from peripheral blood. Here, we validated the …

Despite recent progress in gene-expression profiling studies, the biology underlying the
various patterns of metastasis that are observed in different tumour types remains unclear …

Alterations in gene sequences, expression levels and protein structure or function have
been associated with every type of cancer. These'molecular markers' can be useful in …

Continued elucidation of the genetic changes that drive cancer progression is yielding new
and potentially powerful nucleic acid–based markers of neoplastic disease. Pilot studies …

Metastatic relapse in patients with solid tumors is caused by systemic preoperative or
perioperative dissemination of tumor cells. The presence of individual tumor cells in bone …

The prognosis of cancer patients is largely determined by the occurrence of distant
metastases. In patients with primary tumors, this relapse is mainly due to clinically occult …

Purpose: Numerous studies of circulating epithelial cells (CECs) have been described in
cancer patients, and genetic abnormalities have been well documented. However, with one …

Combining whole genome amplification (WGA) methods with novel laser-based
microdissection techniques has made it possible to exploit recent progress in molecular …