Telomere dynamics in immune senescence and exhaustion triggered by chronic viral infection

M Bellon, C Nicot - Viruses, 2017 - mdpi.com
The progressive loss of immunological memory during aging correlates with a reduced
proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that …

MHC class II tetramers

GT Nepom - The Journal of Immunology, 2012 - journals.aai.org
MHC class II tetramers have emerged as an important tool for characterization of the
specificity and phenotype of CD4 T cell immune responses, useful in a large variety of …

Age at diagnosis, but not HPV type, is strongly associated with clinical course in recurrent respiratory papillomatosis

FJ Buchinsky, WL Valentino, N Ruszkay, E Powell… - PloS one, 2019 - journals.plos.org
Background Recurrent Respiratory Papillomatosis (RRP) is a rare disease characterized by
the growth of papillomas in the airway and especially the larynx. The clinical course is highly …

Altered monocyte and langerhans cell innate immunity in patients with recurrent respiratory papillomatosis (RRP)

M Israr, JA DeVoti, F Lam, AL Abramson… - Frontiers in …, 2020 - frontiersin.org
The micromilieu within respiratory papillomas supports persistent human papillomavirus
(HPV) infection and disease recurrence in patients with recurrent respiratory papillomatosis …

The crossroads: divergent roles of virus‐specific CD4+ T lymphocytes in determining the outcome for human papillomavirus infection

D van Bockel, A Kelleher - Immunology and Cell Biology, 2023 - Wiley Online Library
Despite the widespread availability of effective prophylactic vaccines to prevent human
papillomavirus (HPV) infection, HPV remains a major health burden. For health care …

How enhancing immunity to low‐risk HPV could cure recurrent respiratory papillomatosis

K Bai, C Allen - The Laryngoscope, 2021 - Wiley Online Library
Recurrent respiratory papillomatosis (RRP) is currently treated with repeat surgical resection
of papillomatous disease that does not address the fundamental underlying issue of chronic …

Decreased Langerhans cell responses to IL-36γ: altered innate immunity in patients with recurrent respiratory papillomatosis

J DeVoti, L Hatam, A Lucs, A Afzal, A Abramson… - Molecular …, 2014 - Springer
Recurrent respiratory papillomatosis (RRP) is a rare, chronic disease caused by human
papillomaviruses (HPVs) types 6 and 11 that is characterized by the polarization of adaptive …

TH2-like Chemokine Patterns Correlate with Disease Severity in Patients with Recurrent Respiratory Papillomatosis

DW Rosenthal, JA DeVoti, BM Steinberg… - Molecular …, 2012 - Springer
Recurrent respiratory papillomatosis (RRP), characterized by the recurrent growth of benign
tumors of the respiratory tract, is caused by infection with human papillomavirus (HPV) …

Programmed death-1 (PD-1)-dependent functional impairment of CD4+ T cells in recurrent genital papilloma

DY Chang, SH Song, S You, J Lee, J Kim… - Clinical and …, 2014 - Springer
Genital papilloma is caused by human papilloma virus (HPV) infection and recurs frequently.
Although T cells are known to play a critical role in the control of HPV infection and …

Impaired HPV-specific T-cell response in juvenile-onset recurrent respiratory papillomatosis patients

Y Xi, W Wang, H Wang, X Wang, J Zhang, J Zhao… - Clinical …, 2022 - Elsevier
Immunologic dysfunction is one of the most important mechanisms underlying the initiation
and development of JORRP. The study aimed to explore whether HPV-specific T-cell …