Sporadic Parkinson's disease (PD) is a progressive neurodegenerative disease, with a
complex risk structure thought to be influenced by interactions between genetic variants and …

Fluorescence has long been recognized as a powerful tool for probing biological structure
and function. Nearly sixty-five years ago, Coons and colleagues introduced the first …

Reversible covalent methylation of lysine residues on histone proteins constitutes a principal
molecular mechanism that links chromatin states to diverse biological outcomes. Recently …

In the decade following the publication of the Human Genome, noncoding RNAs (ncRNAs)
have reshaped our understanding of the broad landscape of genome regulation. During this …

Posttranslational modifications play a key role in recruiting chromatin remodeling and
modifying enzymes to specific regions of chromosomes to modulate chromatin structure …

Cervical cancer remains one of the greatest killers of women worldwide. It is difficult to
foresee a dramatic increase in cure rate even with the most optimal combination of cytotoxic …

The genetic code epitomises simplicity, near universality and absolute predictive power. By
contrast, epigenetic information, in the form of histone modifications, is characterised by …

The PHD finger motif is a signature chromatin-associated motif that is found throughout
eukaryotic proteomes. Here we have determined the histone methyl-lysine binding activity of …

The mammalian heart loses its regenerative potential soon after birth. Adult cardiac
myocytes (ACMs) permanently exit the cell cycle, and E2F-dependent genes are stably …

Sex differences in neural development are established via a number of cellular processes
(ie migration, death, and survival). One critical factor identified is the neonatal rise in …