Opioid receptors are widely distributed throughout the brain and play an essential role in
modulating aspects of human mood, reward, and well-being. Accumulating evidence …

Objectives As overdose deaths from fentanyl continue to increase, optimizing use of
medications for opioid use disorder has become increasingly important. Buprenorphine is a …

Importance Patient-reported outcomes in the treatment of opioid dependence may differ
between subcutaneously administered depot buprenorphine and daily sublingual …

In response to the concurrent opioid overdose and COVID-19 epidemics, the United States
(US) Drug Enforcement Administration (DEA) and other federal agencies have taken steps …

Background Unintentional drug overdoses have reached epidemic levels in the US This
study tests the hypothesis that people who have used non-prescribed buprenorphine more …

Objective The COVID-19 pandemic led to unprecedented temporary federal and state
regulatory flexibilities that rapidly transformed medication for opioid use disorder (MOUD) …

Importance Buprenorphine remains underused in treating opioid use disorder, despite its
effectiveness. During the onset of the COVID-19 pandemic, the US government …

Background: Originally believed to be an atypical antidepressant acting at serotonin
transporters, tianeptine is now known to also be an atypical agonist at mu-opioid receptors …

Opioids are widely used in chronic pain management, despite major concerns about their
risk of adverse events, particularly abuse, misuse, and respiratory depression from …

The opioid epidemic, now in its second decade, is one of the most challenging public health
crises in the US. Providing an effective response is complicated by multiple underlying …