Inspired by the biological processes of molecular recognition and transportation across
membranes, nanopore techniques have evolved in recent decades as ultrasensitive …

Bio-markers, such as ions, small molecules, nucleic acids, peptides, proteins and cells,
participate in the construction of living organisms and play important roles in biological …

Glycosaminoglycans (GAGs) are complex polysaccharides exhibiting a vast structural
diversity and fulfilling various functions mediated by thousands of interactions in the …

Understanding and exploring the transport behaviors of ions and molecules in the nano and
sub-nano confinement has great meaning in the fields of nanofluidics and basic transport …

Glycan is a crucial class of biological macromolecules with important biological functions.
Functional groups determine the chemical properties of glycans, which further affect their …

Sequencing of nucleic acids with nanopores has emerged as a powerful tool offering rapid
readout, high accuracy, low cost and portability. This label-free method for sequencing at the …

Fibrosis is a hallmark of aging tissues which often leads to altered architecture and function.
The ovary is the first organ to show overt signs of aging, including increased fibrosis in the …

Conspectus Protein post-translational modifications (PTMs) modulate almost all cellular
processes. Aberrant PTMs are closely bound to various human diseases, which greatly …

Structural complexity of glycans derived from the diversities in composition, linage,
configuration, and branching considerably complicates structural analysis. Nanopore-based …

Glycosaminoglycans are highly anionic functional polysaccharides with information content
in their structure that plays a major role in the communication between the cell and the …