Mast cells (MCs), apart from their classic role in allergy, contribute to a number of biologic
processes including wound healing. In particular, two aspects of their histologic distribution …

All animals heal, and the ability to heal is requisite for human health. One aspect of repair
that has always been considered to be essential for adequate healing is the creation of a …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

Cutaneous fibrosis results from suboptimal wound healing following significant tissue injury
such as severe burns, trauma, and major surgeries. Pathologic skin fibrosis results in scars …

Wound healing is a complex and dynamic process that involves the mediation of many
initiators effective during the healing process such as cytokines, macrophages and …

Wounds in adults are frequently accompanied by scar formation. This scar can become
fibrotic due to an imbalance between extracellular matrix (ECM) synthesis and ECM …

Mast cells (MCs) are granulated, immune cells of the myeloid lineage that are present in
connective tissues. Apart from their classical role in allergies, MCs also mediate various …

Mast cells (MCs) are active participants in blood coagulation and innate and acquired
immunity. This review focuses on the development of mouse and human MCs, as well as the …

Hypertrophic scars and keloids are firm, raised, erythematous plaques or nodules that
manifest when the cicatrix fails to properly heal. They result from pathologic wound healing …

Fibrosis is a medical condition characterized by an excessive deposition of extracellular
matrix compounds such as collagen in tissues. Fibrotic lesions are present in many diseases …