Insertion sequences (ISs), arguably the smallest and most numerous autonomous
transposable elements (TEs), are important players in shaping their host genomes. This …

Crop genomics remains a key element in ensuring scientific progress to secure global food
security. It has been two decades since the sequence of the first plant genome, that of …

The original" Seven Motifs" set forth a roadmap of essential methods for the field of scientific
computing, where a motif is an algorithmic method that captures a pattern of computation …

The interplay of mathematical modelling with experiments is one of the central elements in
systems biology. The aim of reverse engineering is to infer, analyse and understand …

Critical evaluation of the adequacy of ecological models is urgently needed to enhance their
utility in developing theory and enabling environmental managers and policymakers to …

A complete understanding of the brain requires an integrated description of the numerous
scales and levels of neural organization. This means studying the interplay of genes and …

Agent-based modeling is a simulation method in which autonomous agents interact with
their environment and one another, given a predefined set of rules. It is an integral method …

Highlights•We now have metabolic network models; the metabolome is represented by their
nodes.•Metabolite levels are sensitive to changes in enzyme activities.•Drugs hitchhike on …

Quantitative systems pharmacology (QSP) is a quantitative and mechanistic platform
describing the phenotypic interaction between drugs, biological networks, and disease …

This review article considers Earth as an energy-storing (photosynthetic) and energy-
consuming (metabolic) system. We evaluate whether and how photosynthetic, solar fuel …