Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Macrophages reside in virtually every organ. First arising during embryogenesis,
macrophages replenish themselves in the adult through a combination of self-renewal and …

Lipocalin 2 (Lcn2), an innate immune protein, has emerged as a critical iron regulatory
protein during physiological and inflammatory conditions. As a bacteriostatic factor, Lcn2 …

Ketogenesis is a dynamic metabolic conduit supporting hepatic fat oxidation particularly
when carbohydrates are in short supply. Ketone bodies may be recycled into anabolic …

Siderophores are iron chelating molecules produced by nearly all organisms, most notably
by bacteria, to efficiently sequester the limited iron that is available in the environment …

Erythroid progenitors are the largest consumers of iron in the human body. In these cells, a
high flux of iron must reach the mitochondrial matrix to form sufficient heme to support …

Simple Summary Tribbles proteins play various roles in cancer initiation and progression.
However, still little is known about their molecular actions. Here we developed a mass …

The crosstalk between hematopoietic lineages is important for developmental
hematopoiesis. However, the role of primitive red blood cells (RBCs) in the formation of …