Genetics of β-amyloid precursor protein in Alzheimer's disease

TCW Julia, AM Goate - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
Alzheimer's disease (AD) is characterized neuropathologically by neuronal cell loss,
extracellular neuritic plaques composed of β-amyloid (Aβ), and intracellular neurofibrillary …

Molecular mechanisms of metal toxicity in the pathogenesis of Alzheimer's disease

MT Kabir, MS Uddin, S Zaman, Y Begum… - Molecular …, 2021 - Springer
Alzheimer's disease (AD) is the most common form of dementia, which is progressively
affecting elderly people. The dyshomeostasis of biometals and accumulation of toxic metals …

Mechanistic link between vitamin B12 and Alzheimer's disease

AA Lauer, HS Grimm, B Apel, N Golobrodska, L Kruse… - Biomolecules, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …

Amyloid-β as a modulator of synaptic plasticity

MS Parihar, GJ Brewer - Journal of Alzheimer's Disease, 2010 - content.iospress.com
Alzheimer's disease is associated with synapse loss, memory dysfunction, and pathological
accumulation of amyloid-β (Aβ) in plaques. However, an exclusively pathological role for Aβ …

[HTML][HTML] Na+ and K+ ion imbalances in Alzheimer's disease

VM Vitvitsky, SK Garg, RF Keep, RL Albin… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Alzheimer's disease (AD) is associated with impaired glutamate clearance and depressed
Na+/K+ ATPase levels in AD brain that might lead to a cellular ion imbalance. To test this …

Essential oils as a potential neuroprotective remedy for age-related neurodegenerative diseases: A review

A Abd Rashed, AZ Abd Rahman, DNG Rathi - Molecules, 2021 - mdpi.com
Despite the improvements in life expectancy, neurodegenerative conditions have arguably
become the most dreaded maladies of older people. The neuroprotective and anti-ageing …

[HTML][HTML] Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives

RP Bhole, RV Chikhale, KM Rathi - IBRO neuroscience reports, 2024 - Elsevier
Abstract Alzheimer's disease (AD), a progressive degenerative disorder first identified by
Alois Alzheimer in 1907, poses a significant public health challenge. Despite its prevalence …

[6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system

C Lee, GH Park, CY Kim, JH Jang - Food and chemical toxicology, 2011 - Elsevier
Abstract β-Amyloid (Aβ) is involved in the formation of senile plaques, the typical
neuropathological marker for Alzheimer's disease (AD) and has been reported to cause …

Role of amyloid peptides in vascular dysfunction and platelet dysregulation in Alzheimer's disease

I Canobbio, AA Abubaker, C Visconte… - Frontiers in cellular …, 2015 - frontiersin.org
Alzheimer's disease (AD) is the most common neurodegenerative cause of dementia in the
elderly. AD is accompanied by the accumulation of amyloid peptides in the brain …

Neuroprotective effects of salvianolic acid B on an Aβ25–35 peptide-induced mouse model of Alzheimer's disease

YW Lee, DH Kim, SJ Jeon, SJ Park, JM Kim… - European journal of …, 2013 - Elsevier
Salvianolic acid B (SalB) is a polyphenolic compound found in Salvia miltiorrhiza Bunge that
has several anti-oxidative and anti-inflammatory effects. In the present study, we …